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Protein Conservation and Variation Suggest Mechanisms of Cell Type-Specific Modulation of Signaling Pathways

Many proteins and signaling pathways are present in most cell types and tissues and yet perform specialized functions. To elucidate mechanisms by which these ubiquitous pathways are modulated, we overlaid information about cross-cell line protein abundance and variability, and evolutionary conservat...

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Detalles Bibliográficos
Autores principales: Schaefer, Martin H., Yang, Jae-Seong, Serrano, Luis, Kiel, Christina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055412/
https://www.ncbi.nlm.nih.gov/pubmed/24922536
http://dx.doi.org/10.1371/journal.pcbi.1003659