Computational Modeling of Allosteric Regulation in the Hsp90 Chaperones: A Statistical Ensemble Analysis of Protein Structure Networks and Allosteric Communications

A fundamental role of the Hsp90 chaperone in regulating functional activity of diverse protein clients is essential for the integrity of signaling networks. In this work we have combined biophysical simulations of the Hsp90 crystal structures with the protein structure network analysis to characteri...

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Detalles Bibliográficos
Autores principales: Blacklock, Kristin, Verkhivker, Gennady M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055421/
https://www.ncbi.nlm.nih.gov/pubmed/24922508
http://dx.doi.org/10.1371/journal.pcbi.1003679

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055421/
https://www.ncbi.nlm.nih.gov/pubmed/24922508
http://dx.doi.org/10.1371/journal.pcbi.1003679

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