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Gene-Wide Analysis Detects Two New Susceptibility Genes for Alzheimer's Disease

BACKGROUND: Alzheimer's disease is a common debilitating dementia with known heritability, for which 20 late onset susceptibility loci have been identified, but more remain to be discovered. This study sought to identify new susceptibility genes, using an alternative gene-wide analytical approa...

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Autores principales:	Escott-Price, Valentina, Bellenguez, Céline, Wang, Li-San, Choi, Seung-Hoan, Harold, Denise, Jones, Lesley, Holmans, Peter, Gerrish, Amy, Vedernikov, Alexey, Richards, Alexander, DeStefano, Anita L., Lambert, Jean-Charles, Ibrahim-Verbaas, Carla A., Naj, Adam C., Sims, Rebecca, Jun, Gyungah, Bis, Joshua C., Beecham, Gary W., Grenier-Boley, Benjamin, Russo, Giancarlo, Thornton-Wells, Tricia A., Denning, Nicola, Smith, Albert V., Chouraki, Vincent, Thomas, Charlene, Ikram, M. Arfan, Zelenika, Diana, Vardarajan, Badri N., Kamatani, Yoichiro, Lin, Chiao-Feng, Schmidt, Helena, Kunkle, Brian, Dunstan, Melanie L., Vronskaya, Maria, Johnson, Andrew D., Ruiz, Agustin, Bihoreau, Marie-Thérèse, Reitz, Christiane, Pasquier, Florence, Hollingworth, Paul, Hanon, Olivier, Fitzpatrick, Annette L., Buxbaum, Joseph D., Campion, Dominique, Crane, Paul K., Baldwin, Clinton, Becker, Tim, Gudnason, Vilmundur, Cruchaga, Carlos, Craig, David, Amin, Najaf, Berr, Claudine, Lopez, Oscar L., De Jager, Philip L., Deramecourt, Vincent, Johnston, Janet A., Evans, Denis, Lovestone, Simon, Letenneur, Luc, Hernández, Isabel, Rubinsztein, David C., Eiriksdottir, Gudny, Sleegers, Kristel, Goate, Alison M., Fiévet, Nathalie, Huentelman, Matthew J., Gill, Michael, Brown, Kristelle, Kamboh, M. Ilyas, Keller, Lina, Barberger-Gateau, Pascale, McGuinness, Bernadette, Larson, Eric B., Myers, Amanda J., Dufouil, Carole, Todd, Stephen, Wallon, David, Love, Seth, Rogaeva, Ekaterina, Gallacher, John, George-Hyslop, Peter St, Clarimon, Jordi, Lleo, Alberto, Bayer, Anthony, Tsuang, Debby W., Yu, Lei, Tsolaki, Magda, Bossù, Paola, Spalletta, Gianfranco, Proitsi, Petra, Collinge, John, Sorbi, Sandro, Garcia, Florentino Sanchez, Fox, Nick C., Hardy, John, Naranjo, Maria Candida Deniz, Bosco, Paolo, Clarke, Robert, Brayne, Carol, Galimberti, Daniela, Scarpini, Elio, Bonuccelli, Ubaldo, Mancuso, Michelangelo, Siciliano, Gabriele, Moebus, Susanne, Mecocci, Patrizia, Zompo, Maria Del, Maier, Wolfgang, Hampel, Harald, Pilotto, Alberto, Frank-García, Ana, Panza, Francesco, Solfrizzi, Vincenzo, Caffarra, Paolo, Nacmias, Benedetta, Perry, William, Mayhaus, Manuel, Lannfelt, Lars, Hakonarson, Hakon, Pichler, Sabrina, Carrasquillo, Minerva M., Ingelsson, Martin, Beekly, Duane, Alvarez, Victoria, Zou, Fanggeng, Valladares, Otto, Younkin, Steven G., Coto, Eliecer, Hamilton-Nelson, Kara L., Gu, Wei, Razquin, Cristina, Pastor, Pau, Mateo, Ignacio, Owen, Michael J., Faber, Kelley M., Jonsson, Palmi V., Combarros, Onofre, O'Donovan, Michael C., Cantwell, Laura B., Soininen, Hilkka, Blacker, Deborah, Mead, Simon, Mosley, Thomas H., Bennett, David A., Harris, Tamara B., Fratiglioni, Laura, Holmes, Clive, de Bruijn, Renee F. A. G., Passmore, Peter, Montine, Thomas J., Bettens, Karolien, Rotter, Jerome I., Brice, Alexis, Morgan, Kevin, Foroud, Tatiana M., Kukull, Walter A., Hannequin, Didier, Powell, John F., Nalls, Michael A., Ritchie, Karen, Lunetta, Kathryn L., Kauwe, John S. K., Boerwinkle, Eric, Riemenschneider, Matthias, Boada, Mercè, Hiltunen, Mikko, Martin, Eden R., Schmidt, Reinhold, Rujescu, Dan, Dartigues, Jean-François, Mayeux, Richard, Tzourio, Christophe, Hofman, Albert, Nöthen, Markus M., Graff, Caroline, Psaty, Bruce M., Haines, Jonathan L., Lathrop, Mark, Pericak-Vance, Margaret A., Launer, Lenore J., Van Broeckhoven, Christine, Farrer, Lindsay A., van Duijn, Cornelia M., Ramirez, Alfredo, Seshadri, Sudha, Schellenberg, Gerard D., Amouyel, Philippe, Williams, Julie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055488/ https://www.ncbi.nlm.nih.gov/pubmed/24922517 http://dx.doi.org/10.1371/journal.pone.0094661

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author	Escott-Price, Valentina Bellenguez, Céline Wang, Li-San Choi, Seung-Hoan Harold, Denise Jones, Lesley Holmans, Peter Gerrish, Amy Vedernikov, Alexey Richards, Alexander DeStefano, Anita L. Lambert, Jean-Charles Ibrahim-Verbaas, Carla A. Naj, Adam C. Sims, Rebecca Jun, Gyungah Bis, Joshua C. Beecham, Gary W. Grenier-Boley, Benjamin Russo, Giancarlo Thornton-Wells, Tricia A. Denning, Nicola Smith, Albert V. Chouraki, Vincent Thomas, Charlene Ikram, M. Arfan Zelenika, Diana Vardarajan, Badri N. Kamatani, Yoichiro Lin, Chiao-Feng Schmidt, Helena Kunkle, Brian Dunstan, Melanie L. Vronskaya, Maria Johnson, Andrew D. Ruiz, Agustin Bihoreau, Marie-Thérèse Reitz, Christiane Pasquier, Florence Hollingworth, Paul Hanon, Olivier Fitzpatrick, Annette L. Buxbaum, Joseph D. Campion, Dominique Crane, Paul K. Baldwin, Clinton Becker, Tim Gudnason, Vilmundur Cruchaga, Carlos Craig, David Amin, Najaf Berr, Claudine Lopez, Oscar L. De Jager, Philip L. Deramecourt, Vincent Johnston, Janet A. Evans, Denis Lovestone, Simon Letenneur, Luc Hernández, Isabel Rubinsztein, David C. Eiriksdottir, Gudny Sleegers, Kristel Goate, Alison M. Fiévet, Nathalie Huentelman, Matthew J. Gill, Michael Brown, Kristelle Kamboh, M. Ilyas Keller, Lina Barberger-Gateau, Pascale McGuinness, Bernadette Larson, Eric B. Myers, Amanda J. Dufouil, Carole Todd, Stephen Wallon, David Love, Seth Rogaeva, Ekaterina Gallacher, John George-Hyslop, Peter St Clarimon, Jordi Lleo, Alberto Bayer, Anthony Tsuang, Debby W. Yu, Lei Tsolaki, Magda Bossù, Paola Spalletta, Gianfranco Proitsi, Petra Collinge, John Sorbi, Sandro Garcia, Florentino Sanchez Fox, Nick C. Hardy, John Naranjo, Maria Candida Deniz Bosco, Paolo Clarke, Robert Brayne, Carol Galimberti, Daniela Scarpini, Elio Bonuccelli, Ubaldo Mancuso, Michelangelo Siciliano, Gabriele Moebus, Susanne Mecocci, Patrizia Zompo, Maria Del Maier, Wolfgang Hampel, Harald Pilotto, Alberto Frank-García, Ana Panza, Francesco Solfrizzi, Vincenzo Caffarra, Paolo Nacmias, Benedetta Perry, William Mayhaus, Manuel Lannfelt, Lars Hakonarson, Hakon Pichler, Sabrina Carrasquillo, Minerva M. Ingelsson, Martin Beekly, Duane Alvarez, Victoria Zou, Fanggeng Valladares, Otto Younkin, Steven G. Coto, Eliecer Hamilton-Nelson, Kara L. Gu, Wei Razquin, Cristina Pastor, Pau Mateo, Ignacio Owen, Michael J. Faber, Kelley M. Jonsson, Palmi V. Combarros, Onofre O'Donovan, Michael C. Cantwell, Laura B. Soininen, Hilkka Blacker, Deborah Mead, Simon Mosley, Thomas H. Bennett, David A. Harris, Tamara B. Fratiglioni, Laura Holmes, Clive de Bruijn, Renee F. A. G. Passmore, Peter Montine, Thomas J. Bettens, Karolien Rotter, Jerome I. Brice, Alexis Morgan, Kevin Foroud, Tatiana M. Kukull, Walter A. Hannequin, Didier Powell, John F. Nalls, Michael A. Ritchie, Karen Lunetta, Kathryn L. Kauwe, John S. K. Boerwinkle, Eric Riemenschneider, Matthias Boada, Mercè Hiltunen, Mikko Martin, Eden R. Schmidt, Reinhold Rujescu, Dan Dartigues, Jean-François Mayeux, Richard Tzourio, Christophe Hofman, Albert Nöthen, Markus M. Graff, Caroline Psaty, Bruce M. Haines, Jonathan L. Lathrop, Mark Pericak-Vance, Margaret A. Launer, Lenore J. Van Broeckhoven, Christine Farrer, Lindsay A. van Duijn, Cornelia M. Ramirez, Alfredo Seshadri, Sudha Schellenberg, Gerard D. Amouyel, Philippe Williams, Julie
author_facet	Escott-Price, Valentina Bellenguez, Céline Wang, Li-San Choi, Seung-Hoan Harold, Denise Jones, Lesley Holmans, Peter Gerrish, Amy Vedernikov, Alexey Richards, Alexander DeStefano, Anita L. Lambert, Jean-Charles Ibrahim-Verbaas, Carla A. Naj, Adam C. Sims, Rebecca Jun, Gyungah Bis, Joshua C. Beecham, Gary W. Grenier-Boley, Benjamin Russo, Giancarlo Thornton-Wells, Tricia A. Denning, Nicola Smith, Albert V. Chouraki, Vincent Thomas, Charlene Ikram, M. Arfan Zelenika, Diana Vardarajan, Badri N. Kamatani, Yoichiro Lin, Chiao-Feng Schmidt, Helena Kunkle, Brian Dunstan, Melanie L. Vronskaya, Maria Johnson, Andrew D. Ruiz, Agustin Bihoreau, Marie-Thérèse Reitz, Christiane Pasquier, Florence Hollingworth, Paul Hanon, Olivier Fitzpatrick, Annette L. Buxbaum, Joseph D. Campion, Dominique Crane, Paul K. Baldwin, Clinton Becker, Tim Gudnason, Vilmundur Cruchaga, Carlos Craig, David Amin, Najaf Berr, Claudine Lopez, Oscar L. De Jager, Philip L. Deramecourt, Vincent Johnston, Janet A. Evans, Denis Lovestone, Simon Letenneur, Luc Hernández, Isabel Rubinsztein, David C. Eiriksdottir, Gudny Sleegers, Kristel Goate, Alison M. Fiévet, Nathalie Huentelman, Matthew J. Gill, Michael Brown, Kristelle Kamboh, M. Ilyas Keller, Lina Barberger-Gateau, Pascale McGuinness, Bernadette Larson, Eric B. Myers, Amanda J. Dufouil, Carole Todd, Stephen Wallon, David Love, Seth Rogaeva, Ekaterina Gallacher, John George-Hyslop, Peter St Clarimon, Jordi Lleo, Alberto Bayer, Anthony Tsuang, Debby W. Yu, Lei Tsolaki, Magda Bossù, Paola Spalletta, Gianfranco Proitsi, Petra Collinge, John Sorbi, Sandro Garcia, Florentino Sanchez Fox, Nick C. Hardy, John Naranjo, Maria Candida Deniz Bosco, Paolo Clarke, Robert Brayne, Carol Galimberti, Daniela Scarpini, Elio Bonuccelli, Ubaldo Mancuso, Michelangelo Siciliano, Gabriele Moebus, Susanne Mecocci, Patrizia Zompo, Maria Del Maier, Wolfgang Hampel, Harald Pilotto, Alberto Frank-García, Ana Panza, Francesco Solfrizzi, Vincenzo Caffarra, Paolo Nacmias, Benedetta Perry, William Mayhaus, Manuel Lannfelt, Lars Hakonarson, Hakon Pichler, Sabrina Carrasquillo, Minerva M. Ingelsson, Martin Beekly, Duane Alvarez, Victoria Zou, Fanggeng Valladares, Otto Younkin, Steven G. Coto, Eliecer Hamilton-Nelson, Kara L. Gu, Wei Razquin, Cristina Pastor, Pau Mateo, Ignacio Owen, Michael J. Faber, Kelley M. Jonsson, Palmi V. Combarros, Onofre O'Donovan, Michael C. Cantwell, Laura B. Soininen, Hilkka Blacker, Deborah Mead, Simon Mosley, Thomas H. Bennett, David A. Harris, Tamara B. Fratiglioni, Laura Holmes, Clive de Bruijn, Renee F. A. G. Passmore, Peter Montine, Thomas J. Bettens, Karolien Rotter, Jerome I. Brice, Alexis Morgan, Kevin Foroud, Tatiana M. Kukull, Walter A. Hannequin, Didier Powell, John F. Nalls, Michael A. Ritchie, Karen Lunetta, Kathryn L. Kauwe, John S. K. Boerwinkle, Eric Riemenschneider, Matthias Boada, Mercè Hiltunen, Mikko Martin, Eden R. Schmidt, Reinhold Rujescu, Dan Dartigues, Jean-François Mayeux, Richard Tzourio, Christophe Hofman, Albert Nöthen, Markus M. Graff, Caroline Psaty, Bruce M. Haines, Jonathan L. Lathrop, Mark Pericak-Vance, Margaret A. Launer, Lenore J. Van Broeckhoven, Christine Farrer, Lindsay A. van Duijn, Cornelia M. Ramirez, Alfredo Seshadri, Sudha Schellenberg, Gerard D. Amouyel, Philippe Williams, Julie
author_sort	Escott-Price, Valentina
collection	PubMed
description	BACKGROUND: Alzheimer's disease is a common debilitating dementia with known heritability, for which 20 late onset susceptibility loci have been identified, but more remain to be discovered. This study sought to identify new susceptibility genes, using an alternative gene-wide analytical approach which tests for patterns of association within genes, in the powerful genome-wide association dataset of the International Genomics of Alzheimer's Project Consortium, comprising over 7 m genotypes from 25,580 Alzheimer's cases and 48,466 controls. PRINCIPAL FINDINGS: In addition to earlier reported genes, we detected genome-wide significant loci on chromosomes 8 (TP53INP1, p = 1.4×10(−6)) and 14 (IGHV1-67 p = 7.9×10(−8)) which indexed novel susceptibility loci. SIGNIFICANCE: The additional genes identified in this study, have an array of functions previously implicated in Alzheimer's disease, including aspects of energy metabolism, protein degradation and the immune system and add further weight to these pathways as potential therapeutic targets in Alzheimer's disease.
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id	pubmed-4055488
institution	National Center for Biotechnology Information
language	English
publishDate	2014
publisher	Public Library of Science
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spelling	pubmed-40554882014-06-18 Gene-Wide Analysis Detects Two New Susceptibility Genes for Alzheimer's Disease Escott-Price, Valentina Bellenguez, Céline Wang, Li-San Choi, Seung-Hoan Harold, Denise Jones, Lesley Holmans, Peter Gerrish, Amy Vedernikov, Alexey Richards, Alexander DeStefano, Anita L. Lambert, Jean-Charles Ibrahim-Verbaas, Carla A. Naj, Adam C. Sims, Rebecca Jun, Gyungah Bis, Joshua C. Beecham, Gary W. Grenier-Boley, Benjamin Russo, Giancarlo Thornton-Wells, Tricia A. Denning, Nicola Smith, Albert V. Chouraki, Vincent Thomas, Charlene Ikram, M. Arfan Zelenika, Diana Vardarajan, Badri N. Kamatani, Yoichiro Lin, Chiao-Feng Schmidt, Helena Kunkle, Brian Dunstan, Melanie L. Vronskaya, Maria Johnson, Andrew D. Ruiz, Agustin Bihoreau, Marie-Thérèse Reitz, Christiane Pasquier, Florence Hollingworth, Paul Hanon, Olivier Fitzpatrick, Annette L. Buxbaum, Joseph D. Campion, Dominique Crane, Paul K. Baldwin, Clinton Becker, Tim Gudnason, Vilmundur Cruchaga, Carlos Craig, David Amin, Najaf Berr, Claudine Lopez, Oscar L. De Jager, Philip L. Deramecourt, Vincent Johnston, Janet A. Evans, Denis Lovestone, Simon Letenneur, Luc Hernández, Isabel Rubinsztein, David C. Eiriksdottir, Gudny Sleegers, Kristel Goate, Alison M. Fiévet, Nathalie Huentelman, Matthew J. Gill, Michael Brown, Kristelle Kamboh, M. Ilyas Keller, Lina Barberger-Gateau, Pascale McGuinness, Bernadette Larson, Eric B. Myers, Amanda J. Dufouil, Carole Todd, Stephen Wallon, David Love, Seth Rogaeva, Ekaterina Gallacher, John George-Hyslop, Peter St Clarimon, Jordi Lleo, Alberto Bayer, Anthony Tsuang, Debby W. Yu, Lei Tsolaki, Magda Bossù, Paola Spalletta, Gianfranco Proitsi, Petra Collinge, John Sorbi, Sandro Garcia, Florentino Sanchez Fox, Nick C. Hardy, John Naranjo, Maria Candida Deniz Bosco, Paolo Clarke, Robert Brayne, Carol Galimberti, Daniela Scarpini, Elio Bonuccelli, Ubaldo Mancuso, Michelangelo Siciliano, Gabriele Moebus, Susanne Mecocci, Patrizia Zompo, Maria Del Maier, Wolfgang Hampel, Harald Pilotto, Alberto Frank-García, Ana Panza, Francesco Solfrizzi, Vincenzo Caffarra, Paolo Nacmias, Benedetta Perry, William Mayhaus, Manuel Lannfelt, Lars Hakonarson, Hakon Pichler, Sabrina Carrasquillo, Minerva M. Ingelsson, Martin Beekly, Duane Alvarez, Victoria Zou, Fanggeng Valladares, Otto Younkin, Steven G. Coto, Eliecer Hamilton-Nelson, Kara L. Gu, Wei Razquin, Cristina Pastor, Pau Mateo, Ignacio Owen, Michael J. Faber, Kelley M. Jonsson, Palmi V. Combarros, Onofre O'Donovan, Michael C. Cantwell, Laura B. Soininen, Hilkka Blacker, Deborah Mead, Simon Mosley, Thomas H. Bennett, David A. Harris, Tamara B. Fratiglioni, Laura Holmes, Clive de Bruijn, Renee F. A. G. Passmore, Peter Montine, Thomas J. Bettens, Karolien Rotter, Jerome I. Brice, Alexis Morgan, Kevin Foroud, Tatiana M. Kukull, Walter A. Hannequin, Didier Powell, John F. Nalls, Michael A. Ritchie, Karen Lunetta, Kathryn L. Kauwe, John S. K. Boerwinkle, Eric Riemenschneider, Matthias Boada, Mercè Hiltunen, Mikko Martin, Eden R. Schmidt, Reinhold Rujescu, Dan Dartigues, Jean-François Mayeux, Richard Tzourio, Christophe Hofman, Albert Nöthen, Markus M. Graff, Caroline Psaty, Bruce M. Haines, Jonathan L. Lathrop, Mark Pericak-Vance, Margaret A. Launer, Lenore J. Van Broeckhoven, Christine Farrer, Lindsay A. van Duijn, Cornelia M. Ramirez, Alfredo Seshadri, Sudha Schellenberg, Gerard D. Amouyel, Philippe Williams, Julie PLoS One Research Article BACKGROUND: Alzheimer's disease is a common debilitating dementia with known heritability, for which 20 late onset susceptibility loci have been identified, but more remain to be discovered. This study sought to identify new susceptibility genes, using an alternative gene-wide analytical approach which tests for patterns of association within genes, in the powerful genome-wide association dataset of the International Genomics of Alzheimer's Project Consortium, comprising over 7 m genotypes from 25,580 Alzheimer's cases and 48,466 controls. PRINCIPAL FINDINGS: In addition to earlier reported genes, we detected genome-wide significant loci on chromosomes 8 (TP53INP1, p = 1.4×10(−6)) and 14 (IGHV1-67 p = 7.9×10(−8)) which indexed novel susceptibility loci. SIGNIFICANCE: The additional genes identified in this study, have an array of functions previously implicated in Alzheimer's disease, including aspects of energy metabolism, protein degradation and the immune system and add further weight to these pathways as potential therapeutic targets in Alzheimer's disease. Public Library of Science 2014-06-12 /pmc/articles/PMC4055488/ /pubmed/24922517 http://dx.doi.org/10.1371/journal.pone.0094661 Text en https://creativecommons.org/publicdomain/zero/1.0/ This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.
spellingShingle	Research Article Escott-Price, Valentina Bellenguez, Céline Wang, Li-San Choi, Seung-Hoan Harold, Denise Jones, Lesley Holmans, Peter Gerrish, Amy Vedernikov, Alexey Richards, Alexander DeStefano, Anita L. Lambert, Jean-Charles Ibrahim-Verbaas, Carla A. Naj, Adam C. Sims, Rebecca Jun, Gyungah Bis, Joshua C. Beecham, Gary W. Grenier-Boley, Benjamin Russo, Giancarlo Thornton-Wells, Tricia A. Denning, Nicola Smith, Albert V. Chouraki, Vincent Thomas, Charlene Ikram, M. Arfan Zelenika, Diana Vardarajan, Badri N. Kamatani, Yoichiro Lin, Chiao-Feng Schmidt, Helena Kunkle, Brian Dunstan, Melanie L. Vronskaya, Maria Johnson, Andrew D. Ruiz, Agustin Bihoreau, Marie-Thérèse Reitz, Christiane Pasquier, Florence Hollingworth, Paul Hanon, Olivier Fitzpatrick, Annette L. Buxbaum, Joseph D. Campion, Dominique Crane, Paul K. Baldwin, Clinton Becker, Tim Gudnason, Vilmundur Cruchaga, Carlos Craig, David Amin, Najaf Berr, Claudine Lopez, Oscar L. De Jager, Philip L. Deramecourt, Vincent Johnston, Janet A. Evans, Denis Lovestone, Simon Letenneur, Luc Hernández, Isabel Rubinsztein, David C. Eiriksdottir, Gudny Sleegers, Kristel Goate, Alison M. Fiévet, Nathalie Huentelman, Matthew J. Gill, Michael Brown, Kristelle Kamboh, M. Ilyas Keller, Lina Barberger-Gateau, Pascale McGuinness, Bernadette Larson, Eric B. Myers, Amanda J. Dufouil, Carole Todd, Stephen Wallon, David Love, Seth Rogaeva, Ekaterina Gallacher, John George-Hyslop, Peter St Clarimon, Jordi Lleo, Alberto Bayer, Anthony Tsuang, Debby W. Yu, Lei Tsolaki, Magda Bossù, Paola Spalletta, Gianfranco Proitsi, Petra Collinge, John Sorbi, Sandro Garcia, Florentino Sanchez Fox, Nick C. Hardy, John Naranjo, Maria Candida Deniz Bosco, Paolo Clarke, Robert Brayne, Carol Galimberti, Daniela Scarpini, Elio Bonuccelli, Ubaldo Mancuso, Michelangelo Siciliano, Gabriele Moebus, Susanne Mecocci, Patrizia Zompo, Maria Del Maier, Wolfgang Hampel, Harald Pilotto, Alberto Frank-García, Ana Panza, Francesco Solfrizzi, Vincenzo Caffarra, Paolo Nacmias, Benedetta Perry, William Mayhaus, Manuel Lannfelt, Lars Hakonarson, Hakon Pichler, Sabrina Carrasquillo, Minerva M. Ingelsson, Martin Beekly, Duane Alvarez, Victoria Zou, Fanggeng Valladares, Otto Younkin, Steven G. Coto, Eliecer Hamilton-Nelson, Kara L. Gu, Wei Razquin, Cristina Pastor, Pau Mateo, Ignacio Owen, Michael J. Faber, Kelley M. Jonsson, Palmi V. Combarros, Onofre O'Donovan, Michael C. Cantwell, Laura B. Soininen, Hilkka Blacker, Deborah Mead, Simon Mosley, Thomas H. Bennett, David A. Harris, Tamara B. Fratiglioni, Laura Holmes, Clive de Bruijn, Renee F. A. G. Passmore, Peter Montine, Thomas J. Bettens, Karolien Rotter, Jerome I. Brice, Alexis Morgan, Kevin Foroud, Tatiana M. Kukull, Walter A. Hannequin, Didier Powell, John F. Nalls, Michael A. Ritchie, Karen Lunetta, Kathryn L. Kauwe, John S. K. Boerwinkle, Eric Riemenschneider, Matthias Boada, Mercè Hiltunen, Mikko Martin, Eden R. Schmidt, Reinhold Rujescu, Dan Dartigues, Jean-François Mayeux, Richard Tzourio, Christophe Hofman, Albert Nöthen, Markus M. Graff, Caroline Psaty, Bruce M. Haines, Jonathan L. Lathrop, Mark Pericak-Vance, Margaret A. Launer, Lenore J. Van Broeckhoven, Christine Farrer, Lindsay A. van Duijn, Cornelia M. Ramirez, Alfredo Seshadri, Sudha Schellenberg, Gerard D. Amouyel, Philippe Williams, Julie Gene-Wide Analysis Detects Two New Susceptibility Genes for Alzheimer's Disease
title	Gene-Wide Analysis Detects Two New Susceptibility Genes for Alzheimer's Disease
title_full	Gene-Wide Analysis Detects Two New Susceptibility Genes for Alzheimer's Disease
title_fullStr	Gene-Wide Analysis Detects Two New Susceptibility Genes for Alzheimer's Disease
title_full_unstemmed	Gene-Wide Analysis Detects Two New Susceptibility Genes for Alzheimer's Disease
title_short	Gene-Wide Analysis Detects Two New Susceptibility Genes for Alzheimer's Disease
title_sort	gene-wide analysis detects two new susceptibility genes for alzheimer's disease
topic	Research Article
url	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055488/ https://www.ncbi.nlm.nih.gov/pubmed/24922517 http://dx.doi.org/10.1371/journal.pone.0094661
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