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Value of Plasmatic Membrane Attack Complex as a Marker of Severity in Acute Kidney Injury
The aim of this study was to determine if complement pathway is activated in AKI; for this purpose, we measured, through ELISA sandwich, the terminal lytic fraction of the complement system, called membrane attack complex (C5b-C9), in AKI patients compared with patients with similar clinical conditi...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055497/ https://www.ncbi.nlm.nih.gov/pubmed/24967359 http://dx.doi.org/10.1155/2014/361065 |
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author | Rodríguez, Eva Riera, Marta Barrios, Clara Pascual, Julio |
author_facet | Rodríguez, Eva Riera, Marta Barrios, Clara Pascual, Julio |
author_sort | Rodríguez, Eva |
collection | PubMed |
description | The aim of this study was to determine if complement pathway is activated in AKI; for this purpose, we measured, through ELISA sandwich, the terminal lytic fraction of the complement system, called membrane attack complex (C5b-C9), in AKI patients compared with patients with similar clinical conditions but normal renal function. Our data showed that complement system is activated in AKI. Plasmatic MAC concentrations were significantly higher in AKI patients than in those with normal renal function; this difference is maintained independently of the AKI etiology and is proportional to the severity of AKI, measured by ADQI classification. In addition, we found that plasmatic MAC concentrations were significantly higher in patients who did not recover renal function at time of hospitalization discharge, in patients who died during the acute process, and in patients who need renal replacement therapy during hospitalization, but in this last group, the differences did not reach statistical significance. In conclusion, plasmatic MAC concentration seems valuable as a marker of AKI severity. |
format | Online Article Text |
id | pubmed-4055497 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-40554972014-06-25 Value of Plasmatic Membrane Attack Complex as a Marker of Severity in Acute Kidney Injury Rodríguez, Eva Riera, Marta Barrios, Clara Pascual, Julio Biomed Res Int Research Article The aim of this study was to determine if complement pathway is activated in AKI; for this purpose, we measured, through ELISA sandwich, the terminal lytic fraction of the complement system, called membrane attack complex (C5b-C9), in AKI patients compared with patients with similar clinical conditions but normal renal function. Our data showed that complement system is activated in AKI. Plasmatic MAC concentrations were significantly higher in AKI patients than in those with normal renal function; this difference is maintained independently of the AKI etiology and is proportional to the severity of AKI, measured by ADQI classification. In addition, we found that plasmatic MAC concentrations were significantly higher in patients who did not recover renal function at time of hospitalization discharge, in patients who died during the acute process, and in patients who need renal replacement therapy during hospitalization, but in this last group, the differences did not reach statistical significance. In conclusion, plasmatic MAC concentration seems valuable as a marker of AKI severity. Hindawi Publishing Corporation 2014 2014-05-25 /pmc/articles/PMC4055497/ /pubmed/24967359 http://dx.doi.org/10.1155/2014/361065 Text en Copyright © 2014 Eva Rodríguez et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Rodríguez, Eva Riera, Marta Barrios, Clara Pascual, Julio Value of Plasmatic Membrane Attack Complex as a Marker of Severity in Acute Kidney Injury |
title | Value of Plasmatic Membrane Attack Complex as a Marker of Severity in Acute Kidney Injury |
title_full | Value of Plasmatic Membrane Attack Complex as a Marker of Severity in Acute Kidney Injury |
title_fullStr | Value of Plasmatic Membrane Attack Complex as a Marker of Severity in Acute Kidney Injury |
title_full_unstemmed | Value of Plasmatic Membrane Attack Complex as a Marker of Severity in Acute Kidney Injury |
title_short | Value of Plasmatic Membrane Attack Complex as a Marker of Severity in Acute Kidney Injury |
title_sort | value of plasmatic membrane attack complex as a marker of severity in acute kidney injury |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055497/ https://www.ncbi.nlm.nih.gov/pubmed/24967359 http://dx.doi.org/10.1155/2014/361065 |
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