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Value of Plasmatic Membrane Attack Complex as a Marker of Severity in Acute Kidney Injury

The aim of this study was to determine if complement pathway is activated in AKI; for this purpose, we measured, through ELISA sandwich, the terminal lytic fraction of the complement system, called membrane attack complex (C5b-C9), in AKI patients compared with patients with similar clinical conditi...

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Detalles Bibliográficos
Autores principales: Rodríguez, Eva, Riera, Marta, Barrios, Clara, Pascual, Julio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055497/
https://www.ncbi.nlm.nih.gov/pubmed/24967359
http://dx.doi.org/10.1155/2014/361065
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author Rodríguez, Eva
Riera, Marta
Barrios, Clara
Pascual, Julio
author_facet Rodríguez, Eva
Riera, Marta
Barrios, Clara
Pascual, Julio
author_sort Rodríguez, Eva
collection PubMed
description The aim of this study was to determine if complement pathway is activated in AKI; for this purpose, we measured, through ELISA sandwich, the terminal lytic fraction of the complement system, called membrane attack complex (C5b-C9), in AKI patients compared with patients with similar clinical conditions but normal renal function. Our data showed that complement system is activated in AKI. Plasmatic MAC concentrations were significantly higher in AKI patients than in those with normal renal function; this difference is maintained independently of the AKI etiology and is proportional to the severity of AKI, measured by ADQI classification. In addition, we found that plasmatic MAC concentrations were significantly higher in patients who did not recover renal function at time of hospitalization discharge, in patients who died during the acute process, and in patients who need renal replacement therapy during hospitalization, but in this last group, the differences did not reach statistical significance. In conclusion, plasmatic MAC concentration seems valuable as a marker of AKI severity.
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spelling pubmed-40554972014-06-25 Value of Plasmatic Membrane Attack Complex as a Marker of Severity in Acute Kidney Injury Rodríguez, Eva Riera, Marta Barrios, Clara Pascual, Julio Biomed Res Int Research Article The aim of this study was to determine if complement pathway is activated in AKI; for this purpose, we measured, through ELISA sandwich, the terminal lytic fraction of the complement system, called membrane attack complex (C5b-C9), in AKI patients compared with patients with similar clinical conditions but normal renal function. Our data showed that complement system is activated in AKI. Plasmatic MAC concentrations were significantly higher in AKI patients than in those with normal renal function; this difference is maintained independently of the AKI etiology and is proportional to the severity of AKI, measured by ADQI classification. In addition, we found that plasmatic MAC concentrations were significantly higher in patients who did not recover renal function at time of hospitalization discharge, in patients who died during the acute process, and in patients who need renal replacement therapy during hospitalization, but in this last group, the differences did not reach statistical significance. In conclusion, plasmatic MAC concentration seems valuable as a marker of AKI severity. Hindawi Publishing Corporation 2014 2014-05-25 /pmc/articles/PMC4055497/ /pubmed/24967359 http://dx.doi.org/10.1155/2014/361065 Text en Copyright © 2014 Eva Rodríguez et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Rodríguez, Eva
Riera, Marta
Barrios, Clara
Pascual, Julio
Value of Plasmatic Membrane Attack Complex as a Marker of Severity in Acute Kidney Injury
title Value of Plasmatic Membrane Attack Complex as a Marker of Severity in Acute Kidney Injury
title_full Value of Plasmatic Membrane Attack Complex as a Marker of Severity in Acute Kidney Injury
title_fullStr Value of Plasmatic Membrane Attack Complex as a Marker of Severity in Acute Kidney Injury
title_full_unstemmed Value of Plasmatic Membrane Attack Complex as a Marker of Severity in Acute Kidney Injury
title_short Value of Plasmatic Membrane Attack Complex as a Marker of Severity in Acute Kidney Injury
title_sort value of plasmatic membrane attack complex as a marker of severity in acute kidney injury
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055497/
https://www.ncbi.nlm.nih.gov/pubmed/24967359
http://dx.doi.org/10.1155/2014/361065
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