Polymorphisms of β1-Adrenoreceptor Gene and Cardiovascular Complications in Patients with Thyrotoxicosis

Human cardiac β1-AR perform a crucial role in mediating the cardiostimulating effects of norepinephrine. Gly389Arg and Ser49Gly polymorphisms of β1-adrenoreceptors (β1-AR) can influence the cardiovascular prognosis. However, the possible effect of Gly389Arg and Ser49Gly polymorphisms on heart functi...

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Autores principales: Babenko, A. Y., Grineva, E. N., Savitskaja, D. A., Kravchuk, E. N., Solncev, V. N., Kostareva, A. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055531/
https://www.ncbi.nlm.nih.gov/pubmed/24982877
http://dx.doi.org/10.1155/2014/402897
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author Babenko, A. Y.
Grineva, E. N.
Savitskaja, D. A.
Kravchuk, E. N.
Solncev, V. N.
Kostareva, A. A.
author_facet Babenko, A. Y.
Grineva, E. N.
Savitskaja, D. A.
Kravchuk, E. N.
Solncev, V. N.
Kostareva, A. A.
author_sort Babenko, A. Y.
collection PubMed
description Human cardiac β1-AR perform a crucial role in mediating the cardiostimulating effects of norepinephrine. Gly389Arg and Ser49Gly polymorphisms of β1-adrenoreceptors (β1-AR) can influence the cardiovascular prognosis. However, the possible effect of Gly389Arg and Ser49Gly polymorphisms on heart function in thyrotoxicosis has not been studied. We investigated the possible link between Gly389Arg and Ser49Gly polymorphisms and echocardiography parameters in 165 normotensive patients with a thyrotoxicosis without any cardiovascular disorders. Echo-CG was performed according to standard protocol before and during the thyreostatic treatment. Our data demonstrate that both Gly389Arg and Ser49Gly polymorphisms have very moderate influence on the risk of left ventricular hypertrophy and atrial fibrillation with no statistically significant effects on cardiac function and the development of cardiovascular complications.
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spelling pubmed-40555312014-06-30 Polymorphisms of β1-Adrenoreceptor Gene and Cardiovascular Complications in Patients with Thyrotoxicosis Babenko, A. Y. Grineva, E. N. Savitskaja, D. A. Kravchuk, E. N. Solncev, V. N. Kostareva, A. A. Biomed Res Int Research Article Human cardiac β1-AR perform a crucial role in mediating the cardiostimulating effects of norepinephrine. Gly389Arg and Ser49Gly polymorphisms of β1-adrenoreceptors (β1-AR) can influence the cardiovascular prognosis. However, the possible effect of Gly389Arg and Ser49Gly polymorphisms on heart function in thyrotoxicosis has not been studied. We investigated the possible link between Gly389Arg and Ser49Gly polymorphisms and echocardiography parameters in 165 normotensive patients with a thyrotoxicosis without any cardiovascular disorders. Echo-CG was performed according to standard protocol before and during the thyreostatic treatment. Our data demonstrate that both Gly389Arg and Ser49Gly polymorphisms have very moderate influence on the risk of left ventricular hypertrophy and atrial fibrillation with no statistically significant effects on cardiac function and the development of cardiovascular complications. Hindawi Publishing Corporation 2014 2014-05-25 /pmc/articles/PMC4055531/ /pubmed/24982877 http://dx.doi.org/10.1155/2014/402897 Text en Copyright © 2014 A. Y. Babenko et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Babenko, A. Y.
Grineva, E. N.
Savitskaja, D. A.
Kravchuk, E. N.
Solncev, V. N.
Kostareva, A. A.
Polymorphisms of β1-Adrenoreceptor Gene and Cardiovascular Complications in Patients with Thyrotoxicosis
title Polymorphisms of β1-Adrenoreceptor Gene and Cardiovascular Complications in Patients with Thyrotoxicosis
title_full Polymorphisms of β1-Adrenoreceptor Gene and Cardiovascular Complications in Patients with Thyrotoxicosis
title_fullStr Polymorphisms of β1-Adrenoreceptor Gene and Cardiovascular Complications in Patients with Thyrotoxicosis
title_full_unstemmed Polymorphisms of β1-Adrenoreceptor Gene and Cardiovascular Complications in Patients with Thyrotoxicosis
title_short Polymorphisms of β1-Adrenoreceptor Gene and Cardiovascular Complications in Patients with Thyrotoxicosis
title_sort polymorphisms of β1-adrenoreceptor gene and cardiovascular complications in patients with thyrotoxicosis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055531/
https://www.ncbi.nlm.nih.gov/pubmed/24982877
http://dx.doi.org/10.1155/2014/402897
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