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Pfetin as a Risk Factor of Recurrence in Gastrointestinal Stromal Tumors

Background. Despite complete resection of gastrointestinal stromal tumors (GIST), recurrent and/or metastatic disease occurs, often depending on the grade of malignancy. As such, markers are needed that accurately predict patients at high risk for recurrence. Previously our group reported Pfetin as...

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Autores principales: Orita, Hajime, Ito, Tomoaki, Kushida, Tomoyuki, Sakurada, Mutsumi, Maekawa, Hiroshi, Wada, Ryo, Suehara, Yoshiyuki, Kubota, Daisuke, Sato, Koichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055574/
https://www.ncbi.nlm.nih.gov/pubmed/24977158
http://dx.doi.org/10.1155/2014/651935
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author Orita, Hajime
Ito, Tomoaki
Kushida, Tomoyuki
Sakurada, Mutsumi
Maekawa, Hiroshi
Wada, Ryo
Suehara, Yoshiyuki
Kubota, Daisuke
Sato, Koichi
author_facet Orita, Hajime
Ito, Tomoaki
Kushida, Tomoyuki
Sakurada, Mutsumi
Maekawa, Hiroshi
Wada, Ryo
Suehara, Yoshiyuki
Kubota, Daisuke
Sato, Koichi
author_sort Orita, Hajime
collection PubMed
description Background. Despite complete resection of gastrointestinal stromal tumors (GIST), recurrent and/or metastatic disease occurs, often depending on the grade of malignancy. As such, markers are needed that accurately predict patients at high risk for recurrence. Previously our group reported Pfetin as a prognostic biomarker for GIST. In order to create an approach for predicting risk of recurrence, we incorporated Pfetin expression with clinicopathological data to produce a predictive model. Object. Forty-five patients with localized primary GIST were treated with complete gross surgical resection surgically at our institution between 1995 and 2010 were included. The majority of tumors originated in the stomach (38 cases), as well as small intestine (6 cases) and rectum (1 case). Method. (1) We performed retrospective analysis of the connection between Pfetin expression, clinicopathological data, and incidences of recurrence, using bivariate and multivariate analyses. (2) The reactivity of the monoclonal antibody against Pfetin was examined by immunohistochemistry. Pfetin. We have reported Pfetin, identified microarray technology, and compared between statistically different GISTs for good and poor prognoses and for prognostic marker. Results. There were 7 cases of recurrences. (1) By univariate analysis, tumor size, mitoses, exposure to abdominal cavity, and complete tumor removal predicted risk of recurrence. (2) Pfetin-negative cases were significantly related to recurrence (P = 0.002). Conclusions. This analysis demonstrates that lack of Pfetin expression is an additional predictor of recurrence in resected GIST. Further study may determine the role of this variable added to the current predictive model for selection of adjuvant therapy.
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spelling pubmed-40555742014-06-29 Pfetin as a Risk Factor of Recurrence in Gastrointestinal Stromal Tumors Orita, Hajime Ito, Tomoaki Kushida, Tomoyuki Sakurada, Mutsumi Maekawa, Hiroshi Wada, Ryo Suehara, Yoshiyuki Kubota, Daisuke Sato, Koichi Biomed Res Int Research Article Background. Despite complete resection of gastrointestinal stromal tumors (GIST), recurrent and/or metastatic disease occurs, often depending on the grade of malignancy. As such, markers are needed that accurately predict patients at high risk for recurrence. Previously our group reported Pfetin as a prognostic biomarker for GIST. In order to create an approach for predicting risk of recurrence, we incorporated Pfetin expression with clinicopathological data to produce a predictive model. Object. Forty-five patients with localized primary GIST were treated with complete gross surgical resection surgically at our institution between 1995 and 2010 were included. The majority of tumors originated in the stomach (38 cases), as well as small intestine (6 cases) and rectum (1 case). Method. (1) We performed retrospective analysis of the connection between Pfetin expression, clinicopathological data, and incidences of recurrence, using bivariate and multivariate analyses. (2) The reactivity of the monoclonal antibody against Pfetin was examined by immunohistochemistry. Pfetin. We have reported Pfetin, identified microarray technology, and compared between statistically different GISTs for good and poor prognoses and for prognostic marker. Results. There were 7 cases of recurrences. (1) By univariate analysis, tumor size, mitoses, exposure to abdominal cavity, and complete tumor removal predicted risk of recurrence. (2) Pfetin-negative cases were significantly related to recurrence (P = 0.002). Conclusions. This analysis demonstrates that lack of Pfetin expression is an additional predictor of recurrence in resected GIST. Further study may determine the role of this variable added to the current predictive model for selection of adjuvant therapy. Hindawi Publishing Corporation 2014 2014-05-26 /pmc/articles/PMC4055574/ /pubmed/24977158 http://dx.doi.org/10.1155/2014/651935 Text en Copyright © 2014 Hajime Orita et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Orita, Hajime
Ito, Tomoaki
Kushida, Tomoyuki
Sakurada, Mutsumi
Maekawa, Hiroshi
Wada, Ryo
Suehara, Yoshiyuki
Kubota, Daisuke
Sato, Koichi
Pfetin as a Risk Factor of Recurrence in Gastrointestinal Stromal Tumors
title Pfetin as a Risk Factor of Recurrence in Gastrointestinal Stromal Tumors
title_full Pfetin as a Risk Factor of Recurrence in Gastrointestinal Stromal Tumors
title_fullStr Pfetin as a Risk Factor of Recurrence in Gastrointestinal Stromal Tumors
title_full_unstemmed Pfetin as a Risk Factor of Recurrence in Gastrointestinal Stromal Tumors
title_short Pfetin as a Risk Factor of Recurrence in Gastrointestinal Stromal Tumors
title_sort pfetin as a risk factor of recurrence in gastrointestinal stromal tumors
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055574/
https://www.ncbi.nlm.nih.gov/pubmed/24977158
http://dx.doi.org/10.1155/2014/651935
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