Simplagrin, a Platelet Aggregation Inhibitor from Simulium nigrimanum Salivary Glands Specifically Binds to the Von Willebrand Factor Receptor in Collagen and Inhibits Carotid Thrombus Formation In Vivo

BACKGROUND: Among the several challenges faced by bloodsucking arthropods, the vertebrate hemostatic response against blood loss represents an important barrier to efficient blood feeding. Here we report the first inhibitor of collagen-induced platelet aggregation derived from the salivary glands of...

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Detalles Bibliográficos
Autores principales: Chagas, Andrezza C., McPhie, Peter, San, Hong, Narum, David, Reiter, Karine, Tokomasu, Fuyuki, Brayner, Fabio A., Alves, Luiz C., Ribeiro, José M. C., Calvo, Eric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055580/
https://www.ncbi.nlm.nih.gov/pubmed/24921659
http://dx.doi.org/10.1371/journal.pntd.0002947

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