Cytotoxicity of Aporphine, Protoberberine, and Protopine Alkaloids from Dicranostigma leptopodum (Maxim.) Fedde

Nine alkaloids with three different structural skeletons were isolated from Dicranostigma leptopodum (Maxim.) Fedde (Papaveraceae) by repeated silica gel column chromatography. Their chemical structures were identified on the basic of physicochemical and spectroscopic data. Among them, 10-O-methylhe...

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Autores principales: Sun, Ruiqi, Jiang, Haiyan, Zhang, Wenjuan, Yang, Kai, Wang, Chengfang, Fan, Li, He, Qing, Feng, Jiangbin, Du, Shushan, Deng, Zhiwei, Geng, Zhufeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055583/
https://www.ncbi.nlm.nih.gov/pubmed/24963327
http://dx.doi.org/10.1155/2014/580483
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author Sun, Ruiqi
Jiang, Haiyan
Zhang, Wenjuan
Yang, Kai
Wang, Chengfang
Fan, Li
He, Qing
Feng, Jiangbin
Du, Shushan
Deng, Zhiwei
Geng, Zhufeng
author_facet Sun, Ruiqi
Jiang, Haiyan
Zhang, Wenjuan
Yang, Kai
Wang, Chengfang
Fan, Li
He, Qing
Feng, Jiangbin
Du, Shushan
Deng, Zhiwei
Geng, Zhufeng
author_sort Sun, Ruiqi
collection PubMed
description Nine alkaloids with three different structural skeletons were isolated from Dicranostigma leptopodum (Maxim.) Fedde (Papaveraceae) by repeated silica gel column chromatography. Their chemical structures were identified on the basic of physicochemical and spectroscopic data. Among them, 10-O-methylhernovine (1), nantenine (2), corytuberine (3), lagesianine A (4), and dihydrocryptopine (9) were first isolated from this plant. With a series of cytotoxic tests, compounds 2, 3, and 7 displayed cytotoxicity against SMMC-7721 with IC(50) values of 70.08 ± 4.63, 73.22 ± 2.35, and 27.77 ± 2.29 μM, respectively.
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spelling pubmed-40555832014-06-24 Cytotoxicity of Aporphine, Protoberberine, and Protopine Alkaloids from Dicranostigma leptopodum (Maxim.) Fedde Sun, Ruiqi Jiang, Haiyan Zhang, Wenjuan Yang, Kai Wang, Chengfang Fan, Li He, Qing Feng, Jiangbin Du, Shushan Deng, Zhiwei Geng, Zhufeng Evid Based Complement Alternat Med Research Article Nine alkaloids with three different structural skeletons were isolated from Dicranostigma leptopodum (Maxim.) Fedde (Papaveraceae) by repeated silica gel column chromatography. Their chemical structures were identified on the basic of physicochemical and spectroscopic data. Among them, 10-O-methylhernovine (1), nantenine (2), corytuberine (3), lagesianine A (4), and dihydrocryptopine (9) were first isolated from this plant. With a series of cytotoxic tests, compounds 2, 3, and 7 displayed cytotoxicity against SMMC-7721 with IC(50) values of 70.08 ± 4.63, 73.22 ± 2.35, and 27.77 ± 2.29 μM, respectively. Hindawi Publishing Corporation 2014 2014-05-21 /pmc/articles/PMC4055583/ /pubmed/24963327 http://dx.doi.org/10.1155/2014/580483 Text en Copyright © 2014 Ruiqi Sun et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Sun, Ruiqi
Jiang, Haiyan
Zhang, Wenjuan
Yang, Kai
Wang, Chengfang
Fan, Li
He, Qing
Feng, Jiangbin
Du, Shushan
Deng, Zhiwei
Geng, Zhufeng
Cytotoxicity of Aporphine, Protoberberine, and Protopine Alkaloids from Dicranostigma leptopodum (Maxim.) Fedde
title Cytotoxicity of Aporphine, Protoberberine, and Protopine Alkaloids from Dicranostigma leptopodum (Maxim.) Fedde
title_full Cytotoxicity of Aporphine, Protoberberine, and Protopine Alkaloids from Dicranostigma leptopodum (Maxim.) Fedde
title_fullStr Cytotoxicity of Aporphine, Protoberberine, and Protopine Alkaloids from Dicranostigma leptopodum (Maxim.) Fedde
title_full_unstemmed Cytotoxicity of Aporphine, Protoberberine, and Protopine Alkaloids from Dicranostigma leptopodum (Maxim.) Fedde
title_short Cytotoxicity of Aporphine, Protoberberine, and Protopine Alkaloids from Dicranostigma leptopodum (Maxim.) Fedde
title_sort cytotoxicity of aporphine, protoberberine, and protopine alkaloids from dicranostigma leptopodum (maxim.) fedde
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055583/
https://www.ncbi.nlm.nih.gov/pubmed/24963327
http://dx.doi.org/10.1155/2014/580483
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