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Retinoic Acid Therapy Resistance Progresses from Unilineage to Bilineage in HL-60 Leukemic Blasts

Emergent resistance can be progressive and driven by global signaling aberrations. All-trans retinoic acid (RA) is the standard therapeutic agent for acute promyelocytic leukemia, but 10–20% of patients are not responsive, and initially responsive patients relapse and develop retinoic acid resistanc...

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Detalles Bibliográficos
Autores principales:	Jensen, Holly A., Bunaciu, Rodica P., Ibabao, Christopher N., Myers, Rebecca, Varner, Jeffrey D., Yen, Andrew
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055670/ https://www.ncbi.nlm.nih.gov/pubmed/24922062 http://dx.doi.org/10.1371/journal.pone.0098929

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