Bioactivities of Compounds from Elephantopus scaber, an Ethnomedicinal Plant from Southwest China

Elephantopus scaber is an ethnomedicinal plant used by the Zhuang people in Southwest China to treat headaches, colds, diarrhea, hepatitis, and bronchitis. A new δ-truxinate derivative, ethyl, methyl 3,4,3′,4′-tetrahydroxy-δ-truxinate (1), was isolated from the ethyl acetate extract of the entire pl...

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Autores principales: Wang, Jianjun, Li, Ping, Li, Baosai, Guo, Zhiyong, Kennelly, Edward J., Long, Chunlin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055671/
https://www.ncbi.nlm.nih.gov/pubmed/24963325
http://dx.doi.org/10.1155/2014/569594
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author Wang, Jianjun
Li, Ping
Li, Baosai
Guo, Zhiyong
Kennelly, Edward J.
Long, Chunlin
author_facet Wang, Jianjun
Li, Ping
Li, Baosai
Guo, Zhiyong
Kennelly, Edward J.
Long, Chunlin
author_sort Wang, Jianjun
collection PubMed
description Elephantopus scaber is an ethnomedicinal plant used by the Zhuang people in Southwest China to treat headaches, colds, diarrhea, hepatitis, and bronchitis. A new δ-truxinate derivative, ethyl, methyl 3,4,3′,4′-tetrahydroxy-δ-truxinate (1), was isolated from the ethyl acetate extract of the entire plant, along with 4 known compounds. The antioxidant activity of these 5 compounds was determined by ABTS radical scavenging assay. Compound 1 was also tested for its cytotoxicity effect against HepG2 by MTT assay (IC(50) = 60 μM), and its potential anti-inflammatory, antibiotic, and antitumor bioactivities were predicted using target fishing method software.
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spelling pubmed-40556712014-06-24 Bioactivities of Compounds from Elephantopus scaber, an Ethnomedicinal Plant from Southwest China Wang, Jianjun Li, Ping Li, Baosai Guo, Zhiyong Kennelly, Edward J. Long, Chunlin Evid Based Complement Alternat Med Research Article Elephantopus scaber is an ethnomedicinal plant used by the Zhuang people in Southwest China to treat headaches, colds, diarrhea, hepatitis, and bronchitis. A new δ-truxinate derivative, ethyl, methyl 3,4,3′,4′-tetrahydroxy-δ-truxinate (1), was isolated from the ethyl acetate extract of the entire plant, along with 4 known compounds. The antioxidant activity of these 5 compounds was determined by ABTS radical scavenging assay. Compound 1 was also tested for its cytotoxicity effect against HepG2 by MTT assay (IC(50) = 60 μM), and its potential anti-inflammatory, antibiotic, and antitumor bioactivities were predicted using target fishing method software. Hindawi Publishing Corporation 2014 2014-05-19 /pmc/articles/PMC4055671/ /pubmed/24963325 http://dx.doi.org/10.1155/2014/569594 Text en Copyright © 2014 Jianjun Wang et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Wang, Jianjun
Li, Ping
Li, Baosai
Guo, Zhiyong
Kennelly, Edward J.
Long, Chunlin
Bioactivities of Compounds from Elephantopus scaber, an Ethnomedicinal Plant from Southwest China
title Bioactivities of Compounds from Elephantopus scaber, an Ethnomedicinal Plant from Southwest China
title_full Bioactivities of Compounds from Elephantopus scaber, an Ethnomedicinal Plant from Southwest China
title_fullStr Bioactivities of Compounds from Elephantopus scaber, an Ethnomedicinal Plant from Southwest China
title_full_unstemmed Bioactivities of Compounds from Elephantopus scaber, an Ethnomedicinal Plant from Southwest China
title_short Bioactivities of Compounds from Elephantopus scaber, an Ethnomedicinal Plant from Southwest China
title_sort bioactivities of compounds from elephantopus scaber, an ethnomedicinal plant from southwest china
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055671/
https://www.ncbi.nlm.nih.gov/pubmed/24963325
http://dx.doi.org/10.1155/2014/569594
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