Inhibition of the Polyamine System Counteracts β-Amyloid Peptide-Induced Memory Impairment in Mice: Involvement of Extrasynaptic NMDA Receptors

In Alzheimer's disease (AD), the β-amyloid peptide (Aβ) has been causally linked to synaptic dysfunction and cognitive impairment. Several studies have shown that N-Methyl-D-Aspartate receptors (NMDAR) activation is involved in the detrimental actions of Aβ. Polyamines, like spermidine and sper...

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Detalles Bibliográficos
Autores principales: Gomes, Guilherme Monteiro, Dalmolin, Gerusa Duarte, Bär, Julia, Karpova, Anna, Mello, Carlos Fernando, Kreutz, Michael R., Rubin, Maribel Antonello
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055672/
https://www.ncbi.nlm.nih.gov/pubmed/24921942
http://dx.doi.org/10.1371/journal.pone.0099184

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055672/
https://www.ncbi.nlm.nih.gov/pubmed/24921942
http://dx.doi.org/10.1371/journal.pone.0099184

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