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Stereoscopic Analysis of Optic Nerve Head Parameters in Primary Open Angle Glaucoma: The Glaucoma Stereo Analysis Study

PURPOSE: The Glaucoma Stereo Analysis Study (GSAS), a cross sectional multicenter collaborative study, used a stereo fundus camera to assess various morphological parameters of the optic nerve head (ONH) in glaucoma patients and investigated the relationships between these parameters and patient cha...

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Autores principales: Yokoyama, Yu, Tanito, Masaki, Nitta, Koji, Katai, Maki, Kitaoka, Yasushi, Omodaka, Kazuko, Tsuda, Satoru, Nakagawa, Toshiaki, Nakazawa, Toru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055679/
https://www.ncbi.nlm.nih.gov/pubmed/24922327
http://dx.doi.org/10.1371/journal.pone.0099138
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author Yokoyama, Yu
Tanito, Masaki
Nitta, Koji
Katai, Maki
Kitaoka, Yasushi
Omodaka, Kazuko
Tsuda, Satoru
Nakagawa, Toshiaki
Nakazawa, Toru
author_facet Yokoyama, Yu
Tanito, Masaki
Nitta, Koji
Katai, Maki
Kitaoka, Yasushi
Omodaka, Kazuko
Tsuda, Satoru
Nakagawa, Toshiaki
Nakazawa, Toru
author_sort Yokoyama, Yu
collection PubMed
description PURPOSE: The Glaucoma Stereo Analysis Study (GSAS), a cross sectional multicenter collaborative study, used a stereo fundus camera to assess various morphological parameters of the optic nerve head (ONH) in glaucoma patients and investigated the relationships between these parameters and patient characteristics. SUBJECTS AND METHODS: The study included 187 eyes of 187 subjects with primary open angle glaucoma or normal tension glaucoma (male: female  = 100: 87, age  = 61±9 years). Stereo pairs of ONH photographs were made with a stereo fundus camera (nonmyd WX). ONH morphological parameters were calculated with prototype analysis software. In addition to 35 standard parameters, we defined three novel parameters: disc tilt angle, rim decentering, and the absolute value of rim decentering. The correlation between each parameter and patient characteristics was analyzed with Spearman's rank correlation coefficient. RESULTS: Patient characteristics included refractive error of −3.38±3.75 diopters, intraocular pressure (IOP) of 13.6±2.6 mmHg, and visual field mean deviation (MD) of −4.71±3.26 dB. Representative ONH parameters included a horizontal disc width of 1.66±0.28 mm, vertical disc width of 1.86±0.23 mm, disc area of 2.42±0.63 mm(2), cup area of 1.45±0.57 mm(2), and cup volume of 0.31±0.22 mm(3). Correlation analysis revealed significant negative associations between vertical cup-to-disc ratio (0.82±0.08) and MD (r = −0.40, P<0.01) and between disc tilt angle (10.5±12.5 degrees) and refractive error (r = −0.36, P<0.01). Seventy-five percent of the eyes had a positive value for rim decentering (0.30±0.42), indicating that rim thinning manifested more often as an inferior lesion than a superior lesion. CONCLUSION: We used stereoscopic analysis to establish a database of ONH parameters, which may facilitate future studies of glaucomatous changes in ONH morphology.
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spelling pubmed-40556792014-06-18 Stereoscopic Analysis of Optic Nerve Head Parameters in Primary Open Angle Glaucoma: The Glaucoma Stereo Analysis Study Yokoyama, Yu Tanito, Masaki Nitta, Koji Katai, Maki Kitaoka, Yasushi Omodaka, Kazuko Tsuda, Satoru Nakagawa, Toshiaki Nakazawa, Toru PLoS One Research Article PURPOSE: The Glaucoma Stereo Analysis Study (GSAS), a cross sectional multicenter collaborative study, used a stereo fundus camera to assess various morphological parameters of the optic nerve head (ONH) in glaucoma patients and investigated the relationships between these parameters and patient characteristics. SUBJECTS AND METHODS: The study included 187 eyes of 187 subjects with primary open angle glaucoma or normal tension glaucoma (male: female  = 100: 87, age  = 61±9 years). Stereo pairs of ONH photographs were made with a stereo fundus camera (nonmyd WX). ONH morphological parameters were calculated with prototype analysis software. In addition to 35 standard parameters, we defined three novel parameters: disc tilt angle, rim decentering, and the absolute value of rim decentering. The correlation between each parameter and patient characteristics was analyzed with Spearman's rank correlation coefficient. RESULTS: Patient characteristics included refractive error of −3.38±3.75 diopters, intraocular pressure (IOP) of 13.6±2.6 mmHg, and visual field mean deviation (MD) of −4.71±3.26 dB. Representative ONH parameters included a horizontal disc width of 1.66±0.28 mm, vertical disc width of 1.86±0.23 mm, disc area of 2.42±0.63 mm(2), cup area of 1.45±0.57 mm(2), and cup volume of 0.31±0.22 mm(3). Correlation analysis revealed significant negative associations between vertical cup-to-disc ratio (0.82±0.08) and MD (r = −0.40, P<0.01) and between disc tilt angle (10.5±12.5 degrees) and refractive error (r = −0.36, P<0.01). Seventy-five percent of the eyes had a positive value for rim decentering (0.30±0.42), indicating that rim thinning manifested more often as an inferior lesion than a superior lesion. CONCLUSION: We used stereoscopic analysis to establish a database of ONH parameters, which may facilitate future studies of glaucomatous changes in ONH morphology. Public Library of Science 2014-06-12 /pmc/articles/PMC4055679/ /pubmed/24922327 http://dx.doi.org/10.1371/journal.pone.0099138 Text en © 2014 Yokoyama et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Yokoyama, Yu
Tanito, Masaki
Nitta, Koji
Katai, Maki
Kitaoka, Yasushi
Omodaka, Kazuko
Tsuda, Satoru
Nakagawa, Toshiaki
Nakazawa, Toru
Stereoscopic Analysis of Optic Nerve Head Parameters in Primary Open Angle Glaucoma: The Glaucoma Stereo Analysis Study
title Stereoscopic Analysis of Optic Nerve Head Parameters in Primary Open Angle Glaucoma: The Glaucoma Stereo Analysis Study
title_full Stereoscopic Analysis of Optic Nerve Head Parameters in Primary Open Angle Glaucoma: The Glaucoma Stereo Analysis Study
title_fullStr Stereoscopic Analysis of Optic Nerve Head Parameters in Primary Open Angle Glaucoma: The Glaucoma Stereo Analysis Study
title_full_unstemmed Stereoscopic Analysis of Optic Nerve Head Parameters in Primary Open Angle Glaucoma: The Glaucoma Stereo Analysis Study
title_short Stereoscopic Analysis of Optic Nerve Head Parameters in Primary Open Angle Glaucoma: The Glaucoma Stereo Analysis Study
title_sort stereoscopic analysis of optic nerve head parameters in primary open angle glaucoma: the glaucoma stereo analysis study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055679/
https://www.ncbi.nlm.nih.gov/pubmed/24922327
http://dx.doi.org/10.1371/journal.pone.0099138
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