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Modified-Chitosan/siRNA Nanoparticles Downregulate Cellular CDX2 Expression and Cross the Gastric Mucus Barrier

Development of effective non-viral vectors is of crucial importance in the implementation of RNA interference in clinical routine. The localized delivery of siRNAs to the gastrointestinal mucosa is highly desired but faces specific problems such as the stability in gastric acidity conditions and the...

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Detalles Bibliográficos
Autores principales:	Sadio, Ana, Gustafsson, Jenny K., Pereira, Bruno, Gomes, Carla Pereira, Hansson, Gunnar C., David, Leonor, Pêgo, Ana Paula, Almeida, Raquel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055692/ https://www.ncbi.nlm.nih.gov/pubmed/24925340 http://dx.doi.org/10.1371/journal.pone.0099449

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