Protective Efficacy of Passive Immunization with Monoclonal Antibodies in Animal Models of H5N1 Highly Pathogenic Avian Influenza Virus Infection

Highly pathogenic avian influenza (HPAI) viruses of the H5N1 subtype often cause severe pneumonia and multiple organ failure in humans, with reported case fatality rates of more than 60%. To develop a clinical antibody therapy, we generated a human-mouse chimeric monoclonal antibody (MAb) ch61 that...

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Detalles Bibliográficos
Autores principales: Itoh, Yasushi, Yoshida, Reiko, Shichinohe, Shintaro, Higuchi, Megumi, Ishigaki, Hirohito, Nakayama, Misako, Pham, Van Loi, Ishida, Hideaki, Kitano, Mitsutaka, Arikata, Masahiko, Kitagawa, Naoko, Mitsuishi, Yachiyo, Ogasawara, Kazumasa, Tsuchiya, Hideaki, Hiono, Takahiro, Okamatsu, Masatoshi, Sakoda, Yoshihiro, Kida, Hiroshi, Ito, Mutsumi, Quynh Mai, Le, Kawaoka, Yoshihiro, Miyamoto, Hiroko, Ishijima, Mari, Igarashi, Manabu, Suzuki, Yasuhiko, Takada, Ayato
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055766/
https://www.ncbi.nlm.nih.gov/pubmed/24945244
http://dx.doi.org/10.1371/journal.ppat.1004192

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