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Consequences of early postnatal benzodiazepines exposure in rats. II. Social behavior

Social behavior represents an integral part of behavioral repertoire of rats particularly sensitive to pharmacological and environmental influences. The aim of the present study was to investigate whether early postnatal clonazepam (CZP) exposure can induce age-dependent changes related to expressio...

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Autores principales: Mikulecká, Anna, Šubrt, Martin, Pařízková, Martina, Mareš, Pavel, Kubová, Hana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055859/
https://www.ncbi.nlm.nih.gov/pubmed/24982619
http://dx.doi.org/10.3389/fnbeh.2014.00169
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author Mikulecká, Anna
Šubrt, Martin
Pařízková, Martina
Mareš, Pavel
Kubová, Hana
author_facet Mikulecká, Anna
Šubrt, Martin
Pařízková, Martina
Mareš, Pavel
Kubová, Hana
author_sort Mikulecká, Anna
collection PubMed
description Social behavior represents an integral part of behavioral repertoire of rats particularly sensitive to pharmacological and environmental influences. The aim of the present study was to investigate whether early postnatal clonazepam (CZP) exposure can induce age-dependent changes related to expression of social behavior. The drug was administered from postnatal day (P) 7 until P11 at daily doses of 0.1, 0.5 and 1.0 mg/kg i.p. We designed three experiments to assess whether exposure to CZP affects social behavior in respect to the age of rats and the test circumstances, specifically their familiarity with test conditions during adolescence (P32), social behavior in juveniles and adolescents (P18–P42) and social behavior in a resident-intruder paradigm. The frequency and duration of a various patterns of social behavior related to play and social investigation not related to play were evaluated. The results showed that CZP postnatal exposure decreased social play behavior regardless of age and familiarity or unfamiliarity of experimental environment but did not affect the social investigation per se. When rats were confronted with an intruder in their home cages intense wrestling and inhibition of genital investigation were found. In conclusion, these findings show that short-term CZP postnatal exposure inhibits social play behavior and alters specific patterns of social behavior in an age and environment related manner.
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spelling pubmed-40558592014-06-30 Consequences of early postnatal benzodiazepines exposure in rats. II. Social behavior Mikulecká, Anna Šubrt, Martin Pařízková, Martina Mareš, Pavel Kubová, Hana Front Behav Neurosci Neuroscience Social behavior represents an integral part of behavioral repertoire of rats particularly sensitive to pharmacological and environmental influences. The aim of the present study was to investigate whether early postnatal clonazepam (CZP) exposure can induce age-dependent changes related to expression of social behavior. The drug was administered from postnatal day (P) 7 until P11 at daily doses of 0.1, 0.5 and 1.0 mg/kg i.p. We designed three experiments to assess whether exposure to CZP affects social behavior in respect to the age of rats and the test circumstances, specifically their familiarity with test conditions during adolescence (P32), social behavior in juveniles and adolescents (P18–P42) and social behavior in a resident-intruder paradigm. The frequency and duration of a various patterns of social behavior related to play and social investigation not related to play were evaluated. The results showed that CZP postnatal exposure decreased social play behavior regardless of age and familiarity or unfamiliarity of experimental environment but did not affect the social investigation per se. When rats were confronted with an intruder in their home cages intense wrestling and inhibition of genital investigation were found. In conclusion, these findings show that short-term CZP postnatal exposure inhibits social play behavior and alters specific patterns of social behavior in an age and environment related manner. Frontiers Media S.A. 2014-05-08 /pmc/articles/PMC4055859/ /pubmed/24982619 http://dx.doi.org/10.3389/fnbeh.2014.00169 Text en Copyright © 2014 Mikulecká, Šubrt, Pařízková, Mareš and Kubová. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Mikulecká, Anna
Šubrt, Martin
Pařízková, Martina
Mareš, Pavel
Kubová, Hana
Consequences of early postnatal benzodiazepines exposure in rats. II. Social behavior
title Consequences of early postnatal benzodiazepines exposure in rats. II. Social behavior
title_full Consequences of early postnatal benzodiazepines exposure in rats. II. Social behavior
title_fullStr Consequences of early postnatal benzodiazepines exposure in rats. II. Social behavior
title_full_unstemmed Consequences of early postnatal benzodiazepines exposure in rats. II. Social behavior
title_short Consequences of early postnatal benzodiazepines exposure in rats. II. Social behavior
title_sort consequences of early postnatal benzodiazepines exposure in rats. ii. social behavior
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055859/
https://www.ncbi.nlm.nih.gov/pubmed/24982619
http://dx.doi.org/10.3389/fnbeh.2014.00169
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