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In vivo effect of two first-line ART regimens on inflammatory mediators in male HIV patients

BACKGROUND: Persistent immune activation and inflammation are lying behind HIV-infection even in the setting of ART mediated viral suppression. The purpose of this study is to define the in vivo effect of two first-line ART regimens on certain inflammatory mediators in male HIV patients. METHODS: Ma...

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Autores principales: Papakonstantinou, Vasiliki D, Chini, Maria, Mangafas, Nikos, Stamatakis, George M, Tsogas, Nickolaos, Tsoupras, Alexandros B, Psarra, Katherina, Fragopoulou, Elizabeth, Antonopoulou, Smaragdi, Gargalianos, Panagiotis, Demopoulos, Constantinos A, Lazanas, Marios-C
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055908/
https://www.ncbi.nlm.nih.gov/pubmed/24884881
http://dx.doi.org/10.1186/1476-511X-13-90
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author Papakonstantinou, Vasiliki D
Chini, Maria
Mangafas, Nikos
Stamatakis, George M
Tsogas, Nickolaos
Tsoupras, Alexandros B
Psarra, Katherina
Fragopoulou, Elizabeth
Antonopoulou, Smaragdi
Gargalianos, Panagiotis
Demopoulos, Constantinos A
Lazanas, Marios-C
author_facet Papakonstantinou, Vasiliki D
Chini, Maria
Mangafas, Nikos
Stamatakis, George M
Tsogas, Nickolaos
Tsoupras, Alexandros B
Psarra, Katherina
Fragopoulou, Elizabeth
Antonopoulou, Smaragdi
Gargalianos, Panagiotis
Demopoulos, Constantinos A
Lazanas, Marios-C
author_sort Papakonstantinou, Vasiliki D
collection PubMed
description BACKGROUND: Persistent immune activation and inflammation are lying behind HIV-infection even in the setting of ART mediated viral suppression. The purpose of this study is to define the in vivo effect of two first-line ART regimens on certain inflammatory mediators in male HIV patients. METHODS: Male, naive, HIV-infected volunteers were assigned either to tenofovir-DF/emtricitabine/efavirenz (Group_T) or abacavir/lamivudine/efavirenz (Group_A). Platelet Activating Factor (PAF) levels and metabolic enzymes together with HIV-implicated cytokines (IL-1beta, IL-6, IL-8, IL-10, IL-12p70, TNFa) and VEGF were determined for a 12-month period. Differences within each group were determined by non-parametric Friedman and Wilcoxon test, while the differences between the groups were checked by ANOVA repeated measures. RESULTS: Both ART regimens present pronounced effect on inflammatory mediators, resulting in decreased PAF levels and Lipoprotein-associated phospholipase A2 (Lp-PLA2) activity for tenofovir-containing regimen and same as baseline PAF levels with a peak though at the 3(rd) month as well as elevated Lp-PLA2 activity for abacavir-containing regimen. CONCLUSIONS: Studies regarding the effect of first-line ART regimens on inflammation may be beneficial in preventing chronic morbidities during HIV-treatment. From this point of view, the present study suggests an anti-inflammatory effect of tenofovir-containing ART, while the temporary increase of PAF levels in abacavir-containing ART may be the link between the reported cardiovascular risk and abacavir administration.
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spelling pubmed-40559082014-06-14 In vivo effect of two first-line ART regimens on inflammatory mediators in male HIV patients Papakonstantinou, Vasiliki D Chini, Maria Mangafas, Nikos Stamatakis, George M Tsogas, Nickolaos Tsoupras, Alexandros B Psarra, Katherina Fragopoulou, Elizabeth Antonopoulou, Smaragdi Gargalianos, Panagiotis Demopoulos, Constantinos A Lazanas, Marios-C Lipids Health Dis Research BACKGROUND: Persistent immune activation and inflammation are lying behind HIV-infection even in the setting of ART mediated viral suppression. The purpose of this study is to define the in vivo effect of two first-line ART regimens on certain inflammatory mediators in male HIV patients. METHODS: Male, naive, HIV-infected volunteers were assigned either to tenofovir-DF/emtricitabine/efavirenz (Group_T) or abacavir/lamivudine/efavirenz (Group_A). Platelet Activating Factor (PAF) levels and metabolic enzymes together with HIV-implicated cytokines (IL-1beta, IL-6, IL-8, IL-10, IL-12p70, TNFa) and VEGF were determined for a 12-month period. Differences within each group were determined by non-parametric Friedman and Wilcoxon test, while the differences between the groups were checked by ANOVA repeated measures. RESULTS: Both ART regimens present pronounced effect on inflammatory mediators, resulting in decreased PAF levels and Lipoprotein-associated phospholipase A2 (Lp-PLA2) activity for tenofovir-containing regimen and same as baseline PAF levels with a peak though at the 3(rd) month as well as elevated Lp-PLA2 activity for abacavir-containing regimen. CONCLUSIONS: Studies regarding the effect of first-line ART regimens on inflammation may be beneficial in preventing chronic morbidities during HIV-treatment. From this point of view, the present study suggests an anti-inflammatory effect of tenofovir-containing ART, while the temporary increase of PAF levels in abacavir-containing ART may be the link between the reported cardiovascular risk and abacavir administration. BioMed Central 2014-05-29 /pmc/articles/PMC4055908/ /pubmed/24884881 http://dx.doi.org/10.1186/1476-511X-13-90 Text en Copyright © 2014 Papakonstantinou et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Papakonstantinou, Vasiliki D
Chini, Maria
Mangafas, Nikos
Stamatakis, George M
Tsogas, Nickolaos
Tsoupras, Alexandros B
Psarra, Katherina
Fragopoulou, Elizabeth
Antonopoulou, Smaragdi
Gargalianos, Panagiotis
Demopoulos, Constantinos A
Lazanas, Marios-C
In vivo effect of two first-line ART regimens on inflammatory mediators in male HIV patients
title In vivo effect of two first-line ART regimens on inflammatory mediators in male HIV patients
title_full In vivo effect of two first-line ART regimens on inflammatory mediators in male HIV patients
title_fullStr In vivo effect of two first-line ART regimens on inflammatory mediators in male HIV patients
title_full_unstemmed In vivo effect of two first-line ART regimens on inflammatory mediators in male HIV patients
title_short In vivo effect of two first-line ART regimens on inflammatory mediators in male HIV patients
title_sort in vivo effect of two first-line art regimens on inflammatory mediators in male hiv patients
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055908/
https://www.ncbi.nlm.nih.gov/pubmed/24884881
http://dx.doi.org/10.1186/1476-511X-13-90
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