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A Meta-Analysis of Hodgkin Lymphoma Reveals 19p13.3 TCF3 as a Novel Susceptibility Locus
Recent genome wide association studies (GWAS) of Hodgkin lymphoma (HL) have identified associations with genetic variation at both HLA and non-HLA loci; however, much of heritable HL susceptibility remains unexplained. Here we perform a meta-analysis of three HL GWAS totaling 1,816 cases and 7,877 c...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055950/ https://www.ncbi.nlm.nih.gov/pubmed/24920014 http://dx.doi.org/10.1038/ncomms4856 |
| _version_ | 1782320756342915072 |
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| author | Cozen, W Timofeeva, MN Li, D Diepstra, A Hazelett, D Delahaye-Sourdeix, M Edlund, CK Franke, L Rostgaard, K Van Den Berg, DJ Cortessis, VK Smedby, KE Glaser, SL H-J, Westra Robison, LL Mack, TM Ghesquieres, H Hwang, AE Nieters, A de Sanjose, S Lightfoot, T Becker, N Maynadie, M Foretova, L Roman, E Benavente, Y Rand, KA Nathwani, BN Glimelius, B Staines, A Boffetta, P Link, BK Kiemeney, L Ansell, SM Bhatia, S Strong, LC Galan, P Vatten, L Habermann, TM Duell, EJ Lake, A Veenstra, RN Visser, L Liu, Y Urayama, KY Montgomery, D Gaborieau, V Weiss, LM Byrnes, G Lathrop, M Cocco, P Best, T Skol, AD H-O, Adami Melbye, M Cerhan, JR Gallagher, A Taylor, GM Slager, SL Brennan, P Coetzee, GA Conti, DV Onel, K Jarrett, RF Hjalgrim, H van den Berg, A McKay, JD |
| author_facet | Cozen, W Timofeeva, MN Li, D Diepstra, A Hazelett, D Delahaye-Sourdeix, M Edlund, CK Franke, L Rostgaard, K Van Den Berg, DJ Cortessis, VK Smedby, KE Glaser, SL H-J, Westra Robison, LL Mack, TM Ghesquieres, H Hwang, AE Nieters, A de Sanjose, S Lightfoot, T Becker, N Maynadie, M Foretova, L Roman, E Benavente, Y Rand, KA Nathwani, BN Glimelius, B Staines, A Boffetta, P Link, BK Kiemeney, L Ansell, SM Bhatia, S Strong, LC Galan, P Vatten, L Habermann, TM Duell, EJ Lake, A Veenstra, RN Visser, L Liu, Y Urayama, KY Montgomery, D Gaborieau, V Weiss, LM Byrnes, G Lathrop, M Cocco, P Best, T Skol, AD H-O, Adami Melbye, M Cerhan, JR Gallagher, A Taylor, GM Slager, SL Brennan, P Coetzee, GA Conti, DV Onel, K Jarrett, RF Hjalgrim, H van den Berg, A McKay, JD |
| author_sort | Cozen, W |
| collection | PubMed |
| description | Recent genome wide association studies (GWAS) of Hodgkin lymphoma (HL) have identified associations with genetic variation at both HLA and non-HLA loci; however, much of heritable HL susceptibility remains unexplained. Here we perform a meta-analysis of three HL GWAS totaling 1,816 cases and 7,877 controls followed by replication in an independent set of 1,281 cases and 3,218 controls to find novel risk loci. We identify a novel variant at 19p13.3 associated with HL (rs1860661; odds ratio [OR] = 0.81, 95% confidence interval [95% CI] = 0.76–0.86, P(combined) = 3.5 × 10(−10)), located in intron 2 of TCF3 (also known as E2A), a regulator of B- and T-cell lineage commitment known to be involved in HL pathogenesis. This meta-analysis also notes associations between previously published loci at 2p16.1, 5q31, 6p31.2, 8q24.21 and 10p14 and HL subtypes. We conclude that our data suggest a link between the 19p13.3 locus, including TCF3, and HL risk |
| format | Online Article Text |
| id | pubmed-4055950 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2014 |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-40559502014-12-12 A Meta-Analysis of Hodgkin Lymphoma Reveals 19p13.3 TCF3 as a Novel Susceptibility Locus Cozen, W Timofeeva, MN Li, D Diepstra, A Hazelett, D Delahaye-Sourdeix, M Edlund, CK Franke, L Rostgaard, K Van Den Berg, DJ Cortessis, VK Smedby, KE Glaser, SL H-J, Westra Robison, LL Mack, TM Ghesquieres, H Hwang, AE Nieters, A de Sanjose, S Lightfoot, T Becker, N Maynadie, M Foretova, L Roman, E Benavente, Y Rand, KA Nathwani, BN Glimelius, B Staines, A Boffetta, P Link, BK Kiemeney, L Ansell, SM Bhatia, S Strong, LC Galan, P Vatten, L Habermann, TM Duell, EJ Lake, A Veenstra, RN Visser, L Liu, Y Urayama, KY Montgomery, D Gaborieau, V Weiss, LM Byrnes, G Lathrop, M Cocco, P Best, T Skol, AD H-O, Adami Melbye, M Cerhan, JR Gallagher, A Taylor, GM Slager, SL Brennan, P Coetzee, GA Conti, DV Onel, K Jarrett, RF Hjalgrim, H van den Berg, A McKay, JD Nat Commun Article Recent genome wide association studies (GWAS) of Hodgkin lymphoma (HL) have identified associations with genetic variation at both HLA and non-HLA loci; however, much of heritable HL susceptibility remains unexplained. Here we perform a meta-analysis of three HL GWAS totaling 1,816 cases and 7,877 controls followed by replication in an independent set of 1,281 cases and 3,218 controls to find novel risk loci. We identify a novel variant at 19p13.3 associated with HL (rs1860661; odds ratio [OR] = 0.81, 95% confidence interval [95% CI] = 0.76–0.86, P(combined) = 3.5 × 10(−10)), located in intron 2 of TCF3 (also known as E2A), a regulator of B- and T-cell lineage commitment known to be involved in HL pathogenesis. This meta-analysis also notes associations between previously published loci at 2p16.1, 5q31, 6p31.2, 8q24.21 and 10p14 and HL subtypes. We conclude that our data suggest a link between the 19p13.3 locus, including TCF3, and HL risk 2014-06-12 /pmc/articles/PMC4055950/ /pubmed/24920014 http://dx.doi.org/10.1038/ncomms4856 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
| spellingShingle | Article Cozen, W Timofeeva, MN Li, D Diepstra, A Hazelett, D Delahaye-Sourdeix, M Edlund, CK Franke, L Rostgaard, K Van Den Berg, DJ Cortessis, VK Smedby, KE Glaser, SL H-J, Westra Robison, LL Mack, TM Ghesquieres, H Hwang, AE Nieters, A de Sanjose, S Lightfoot, T Becker, N Maynadie, M Foretova, L Roman, E Benavente, Y Rand, KA Nathwani, BN Glimelius, B Staines, A Boffetta, P Link, BK Kiemeney, L Ansell, SM Bhatia, S Strong, LC Galan, P Vatten, L Habermann, TM Duell, EJ Lake, A Veenstra, RN Visser, L Liu, Y Urayama, KY Montgomery, D Gaborieau, V Weiss, LM Byrnes, G Lathrop, M Cocco, P Best, T Skol, AD H-O, Adami Melbye, M Cerhan, JR Gallagher, A Taylor, GM Slager, SL Brennan, P Coetzee, GA Conti, DV Onel, K Jarrett, RF Hjalgrim, H van den Berg, A McKay, JD A Meta-Analysis of Hodgkin Lymphoma Reveals 19p13.3 TCF3 as a Novel Susceptibility Locus |
| title | A Meta-Analysis of Hodgkin Lymphoma Reveals 19p13.3 TCF3 as a Novel Susceptibility Locus |
| title_full | A Meta-Analysis of Hodgkin Lymphoma Reveals 19p13.3 TCF3 as a Novel Susceptibility Locus |
| title_fullStr | A Meta-Analysis of Hodgkin Lymphoma Reveals 19p13.3 TCF3 as a Novel Susceptibility Locus |
| title_full_unstemmed | A Meta-Analysis of Hodgkin Lymphoma Reveals 19p13.3 TCF3 as a Novel Susceptibility Locus |
| title_short | A Meta-Analysis of Hodgkin Lymphoma Reveals 19p13.3 TCF3 as a Novel Susceptibility Locus |
| title_sort | meta-analysis of hodgkin lymphoma reveals 19p13.3 tcf3 as a novel susceptibility locus |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4055950/ https://www.ncbi.nlm.nih.gov/pubmed/24920014 http://dx.doi.org/10.1038/ncomms4856 |
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