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Orbitofrontal neurons infer the value and identity of predicted outcomes

The best way to respond flexibly to changes in the environment is to anticipate them. Such anticipation often benefits us if we can infer that a change has occurred, before we have actually experienced the effects of that change. Here we test for neural correlates of this process by recording single...

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Autores principales: Stalnaker, Thomas A., Cooch, Nisha K., McDannald, Michael A., Liu, Tzu-Lan, Wied, Heather, Schoenbaum, Geoffrey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4056018/
https://www.ncbi.nlm.nih.gov/pubmed/24894805
http://dx.doi.org/10.1038/ncomms4926
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author Stalnaker, Thomas A.
Cooch, Nisha K.
McDannald, Michael A.
Liu, Tzu-Lan
Wied, Heather
Schoenbaum, Geoffrey
author_facet Stalnaker, Thomas A.
Cooch, Nisha K.
McDannald, Michael A.
Liu, Tzu-Lan
Wied, Heather
Schoenbaum, Geoffrey
author_sort Stalnaker, Thomas A.
collection PubMed
description The best way to respond flexibly to changes in the environment is to anticipate them. Such anticipation often benefits us if we can infer that a change has occurred, before we have actually experienced the effects of that change. Here we test for neural correlates of this process by recording single-unit activity in the orbitofrontal cortex in rats performing a choice task in which the available rewards changed across blocks of trials. Consistent with the proposal that orbitofrontal cortex signals inferred information, firing changes at the start of each new block as if predicting the not-yet-experienced reward. This change occurs whether the new reward is different in number of drops, requiring signaling of a new value, or in flavor, requiring signaling of a new sensory feature. These results show that orbitofrontal neurons provide a behaviorally relevant signal that reflects inferences about both value-relevant and value-neutral information about impending outcomes.
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spelling pubmed-40560182014-12-04 Orbitofrontal neurons infer the value and identity of predicted outcomes Stalnaker, Thomas A. Cooch, Nisha K. McDannald, Michael A. Liu, Tzu-Lan Wied, Heather Schoenbaum, Geoffrey Nat Commun Article The best way to respond flexibly to changes in the environment is to anticipate them. Such anticipation often benefits us if we can infer that a change has occurred, before we have actually experienced the effects of that change. Here we test for neural correlates of this process by recording single-unit activity in the orbitofrontal cortex in rats performing a choice task in which the available rewards changed across blocks of trials. Consistent with the proposal that orbitofrontal cortex signals inferred information, firing changes at the start of each new block as if predicting the not-yet-experienced reward. This change occurs whether the new reward is different in number of drops, requiring signaling of a new value, or in flavor, requiring signaling of a new sensory feature. These results show that orbitofrontal neurons provide a behaviorally relevant signal that reflects inferences about both value-relevant and value-neutral information about impending outcomes. 2014-06-04 /pmc/articles/PMC4056018/ /pubmed/24894805 http://dx.doi.org/10.1038/ncomms4926 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Stalnaker, Thomas A.
Cooch, Nisha K.
McDannald, Michael A.
Liu, Tzu-Lan
Wied, Heather
Schoenbaum, Geoffrey
Orbitofrontal neurons infer the value and identity of predicted outcomes
title Orbitofrontal neurons infer the value and identity of predicted outcomes
title_full Orbitofrontal neurons infer the value and identity of predicted outcomes
title_fullStr Orbitofrontal neurons infer the value and identity of predicted outcomes
title_full_unstemmed Orbitofrontal neurons infer the value and identity of predicted outcomes
title_short Orbitofrontal neurons infer the value and identity of predicted outcomes
title_sort orbitofrontal neurons infer the value and identity of predicted outcomes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4056018/
https://www.ncbi.nlm.nih.gov/pubmed/24894805
http://dx.doi.org/10.1038/ncomms4926
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