Exogenous administration of protease-resistant, non-matrix-binding IGFBP-2 inhibits tumour growth in a murine model of breast cancer

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BACKGROUND: Insulin-like growth factors (IGF-I and IGF-II) signal via the type 1 IGF receptor (IGF-1R) and IGF-II also activates the insulin receptor isoform A (IR-A). Signalling via both receptors promotes tumour growth, survival and metastasis. In some instances IGF-II action via the IR-A also pro...

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Detalles Bibliográficos
Autores principales: Soh, C-L, McNeil, K, Owczarek, C M, Hardy, M P, Fabri, L J, Pearse, M, Delaine, C A, Forbes, B E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Translational Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4056053/
https://www.ncbi.nlm.nih.gov/pubmed/24853186
http://dx.doi.org/10.1038/bjc.2014.232
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