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Of ions and temperature: the complicated interplay of temperature, fluids, and electrolytes on myocardial function

This article discusses the potential of levosimendan to treat calcium-induced myocardial dysfunction associated with deep hypothermia. Moderate hypothermia (30 to 34°C) usually improves myocardial contractility and stabilizes heart rhythm, but deep hypothermia can cause severe myocardial dysfunction...

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Detalles Bibliográficos
Autor principal: Polderman, Kees H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4056327/
https://www.ncbi.nlm.nih.gov/pubmed/24313967
http://dx.doi.org/10.1186/cc13139
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author Polderman, Kees H
author_facet Polderman, Kees H
author_sort Polderman, Kees H
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description This article discusses the potential of levosimendan to treat calcium-induced myocardial dysfunction associated with deep hypothermia. Moderate hypothermia (30 to 34°C) usually improves myocardial contractility and stabilizes heart rhythm, but deep hypothermia can cause severe myocardial dysfunction, which is mediated by intracellular calcium overload. In experimental studies, levosimendan appears effective in reversing this. Clinical studies are needed to confirm these findings and to determine whether levosimendan could also be used for accidental hypothermia and perhaps to mitigate diastolic dysfunction under moderate hypothermia.
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spelling pubmed-40563272014-12-04 Of ions and temperature: the complicated interplay of temperature, fluids, and electrolytes on myocardial function Polderman, Kees H Crit Care Commentary This article discusses the potential of levosimendan to treat calcium-induced myocardial dysfunction associated with deep hypothermia. Moderate hypothermia (30 to 34°C) usually improves myocardial contractility and stabilizes heart rhythm, but deep hypothermia can cause severe myocardial dysfunction, which is mediated by intracellular calcium overload. In experimental studies, levosimendan appears effective in reversing this. Clinical studies are needed to confirm these findings and to determine whether levosimendan could also be used for accidental hypothermia and perhaps to mitigate diastolic dysfunction under moderate hypothermia. BioMed Central 2013 2013-12-04 /pmc/articles/PMC4056327/ /pubmed/24313967 http://dx.doi.org/10.1186/cc13139 Text en Copyright © 2013 BioMed Central Ltd.
spellingShingle Commentary
Polderman, Kees H
Of ions and temperature: the complicated interplay of temperature, fluids, and electrolytes on myocardial function
title Of ions and temperature: the complicated interplay of temperature, fluids, and electrolytes on myocardial function
title_full Of ions and temperature: the complicated interplay of temperature, fluids, and electrolytes on myocardial function
title_fullStr Of ions and temperature: the complicated interplay of temperature, fluids, and electrolytes on myocardial function
title_full_unstemmed Of ions and temperature: the complicated interplay of temperature, fluids, and electrolytes on myocardial function
title_short Of ions and temperature: the complicated interplay of temperature, fluids, and electrolytes on myocardial function
title_sort of ions and temperature: the complicated interplay of temperature, fluids, and electrolytes on myocardial function
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4056327/
https://www.ncbi.nlm.nih.gov/pubmed/24313967
http://dx.doi.org/10.1186/cc13139
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