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Of ions and temperature: the complicated interplay of temperature, fluids, and electrolytes on myocardial function
This article discusses the potential of levosimendan to treat calcium-induced myocardial dysfunction associated with deep hypothermia. Moderate hypothermia (30 to 34°C) usually improves myocardial contractility and stabilizes heart rhythm, but deep hypothermia can cause severe myocardial dysfunction...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2013
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4056327/ https://www.ncbi.nlm.nih.gov/pubmed/24313967 http://dx.doi.org/10.1186/cc13139 |
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author | Polderman, Kees H |
author_facet | Polderman, Kees H |
author_sort | Polderman, Kees H |
collection | PubMed |
description | This article discusses the potential of levosimendan to treat calcium-induced myocardial dysfunction associated with deep hypothermia. Moderate hypothermia (30 to 34°C) usually improves myocardial contractility and stabilizes heart rhythm, but deep hypothermia can cause severe myocardial dysfunction, which is mediated by intracellular calcium overload. In experimental studies, levosimendan appears effective in reversing this. Clinical studies are needed to confirm these findings and to determine whether levosimendan could also be used for accidental hypothermia and perhaps to mitigate diastolic dysfunction under moderate hypothermia. |
format | Online Article Text |
id | pubmed-4056327 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-40563272014-12-04 Of ions and temperature: the complicated interplay of temperature, fluids, and electrolytes on myocardial function Polderman, Kees H Crit Care Commentary This article discusses the potential of levosimendan to treat calcium-induced myocardial dysfunction associated with deep hypothermia. Moderate hypothermia (30 to 34°C) usually improves myocardial contractility and stabilizes heart rhythm, but deep hypothermia can cause severe myocardial dysfunction, which is mediated by intracellular calcium overload. In experimental studies, levosimendan appears effective in reversing this. Clinical studies are needed to confirm these findings and to determine whether levosimendan could also be used for accidental hypothermia and perhaps to mitigate diastolic dysfunction under moderate hypothermia. BioMed Central 2013 2013-12-04 /pmc/articles/PMC4056327/ /pubmed/24313967 http://dx.doi.org/10.1186/cc13139 Text en Copyright © 2013 BioMed Central Ltd. |
spellingShingle | Commentary Polderman, Kees H Of ions and temperature: the complicated interplay of temperature, fluids, and electrolytes on myocardial function |
title | Of ions and temperature: the complicated interplay of temperature, fluids, and electrolytes on myocardial function |
title_full | Of ions and temperature: the complicated interplay of temperature, fluids, and electrolytes on myocardial function |
title_fullStr | Of ions and temperature: the complicated interplay of temperature, fluids, and electrolytes on myocardial function |
title_full_unstemmed | Of ions and temperature: the complicated interplay of temperature, fluids, and electrolytes on myocardial function |
title_short | Of ions and temperature: the complicated interplay of temperature, fluids, and electrolytes on myocardial function |
title_sort | of ions and temperature: the complicated interplay of temperature, fluids, and electrolytes on myocardial function |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4056327/ https://www.ncbi.nlm.nih.gov/pubmed/24313967 http://dx.doi.org/10.1186/cc13139 |
work_keys_str_mv | AT poldermankeesh ofionsandtemperaturethecomplicatedinterplayoftemperaturefluidsandelectrolytesonmyocardialfunction |