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Isotype Switching Increases Efficacy of Antibody Protection against Staphylococcal Enterotoxin B-Induced Lethal Shock and Staphylococcus aureus Sepsis in Mice
Staphylococcal enterotoxin B (SEB) is a potent toxin that is produced by Staphylococcus aureus strains and is classified as a category B select agent. We have previously shown that monoclonal antibody (MAb) 20B1, a murine anti-SEB IgG1, successfully treats SEB-induced lethal shock (SEBILS) and bacte...
Autores principales: | Varshney, Avanish K., Wang, Xiaobo, Aguilar, Jorge L., Scharff, Matthew D., Fries, Bettina C. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society of Microbiology
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4056548/ https://www.ncbi.nlm.nih.gov/pubmed/24917594 http://dx.doi.org/10.1128/mBio.01007-14 |
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