Detrimental role of humoral signalling in cardio-renal cross-talk

In critically ill patients, any acute organ injury is associated with a sudden change of circulating factors that may play a role in distant organ dysfunction through a complex cross-talk. In this issue, Virzì and colleagues discuss the relevance of humoral signalling between heart and kidney, focus...

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Detalles Bibliográficos
Autores principales: Cantaluppi, Vincenzo, Dellepiane, Sergio, Quercia, Alessandro D, Ferrario, Silvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4056806/
https://www.ncbi.nlm.nih.gov/pubmed/24451176
http://dx.doi.org/10.1186/cc13704
Descripción
Sumario:In critically ill patients, any acute organ injury is associated with a sudden change of circulating factors that may play a role in distant organ dysfunction through a complex cross-talk. In this issue, Virzì and colleagues discuss the relevance of humoral signalling between heart and kidney, focusing on type 1 and type 3 cardio-renal syndrome. We herein review the mechanisms of heart-kidney cross-talk, discussing the role of circulating detrimental mediators in the pathogenetic mechanisms of cardio-renal syndrome.

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