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Diabetes Mellitus and Risk of Thyroid Cancer: A Meta-Analysis
INTRODUCTION: Diabetes mellitus (DM) is an important risk factor for endocrine cancers; however, the association with thyroid cancer is not clear. We performed a systematic review and meta-analysis to clarify the association between thyroid cancer and DM. METHODS: We searched MEDLINE, PUBMED and EMB...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057085/ https://www.ncbi.nlm.nih.gov/pubmed/24927125 http://dx.doi.org/10.1371/journal.pone.0098135 |
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author | Yeo, Yohwan Ma, Seung-Hyun Hwang, Yunji Horn-Ross, Pamela L. Hsing, Ann Lee, Kyu-Eun Park, Young Joo Park, Do-Joon Yoo, Keun-Young Park, Sue K. |
author_facet | Yeo, Yohwan Ma, Seung-Hyun Hwang, Yunji Horn-Ross, Pamela L. Hsing, Ann Lee, Kyu-Eun Park, Young Joo Park, Do-Joon Yoo, Keun-Young Park, Sue K. |
author_sort | Yeo, Yohwan |
collection | PubMed |
description | INTRODUCTION: Diabetes mellitus (DM) is an important risk factor for endocrine cancers; however, the association with thyroid cancer is not clear. We performed a systematic review and meta-analysis to clarify the association between thyroid cancer and DM. METHODS: We searched MEDLINE, PUBMED and EMBASE databases through July 2012, using search terms related to diabetes mellitus, cancer, and thyroid cancer. We conducted a meta-analysis of the risk of incidence of thyroid cancer from pre-existing diabetes. Of 2,123 titles initially identified, sixteen articles met our inclusion criteria. An additional article was identified from a bibliography. Totally, 14 cohort and 3 case-control studies were selected for the meta-analysis. The risks were estimated using random-effects model and sensitivity test for the studies which reported risk estimates and used different definition of DM. RESULTS: Compared with individuals without DM, the patients with DM were at 1.34-fold higher risk for thyroid cancer (95% CI 1.11–1.63). However, there was heterogeneity in the results (p<0.0001). Sensitivity tests and studies judged to be high quality did not show heterogeneity and DM was associated with higher risk for thyroid cancer in these sub-analyses (both of RRs = 1.18, 95% CIs 1.08–1.28). DM was associated with a 1.38-fold increased risk of thyroid cancer in women (95% CI 1.13–1.67) after sensitivity test. Risk of thyroid cancer in men did not remain significant (RR 1.11, 95% CI 0.80–1.53). CONCLUSIONS: Compared with their non-diabetic counterparts, women with pre-existing DM have an increased risk of thyroid cancer. |
format | Online Article Text |
id | pubmed-4057085 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-40570852014-06-18 Diabetes Mellitus and Risk of Thyroid Cancer: A Meta-Analysis Yeo, Yohwan Ma, Seung-Hyun Hwang, Yunji Horn-Ross, Pamela L. Hsing, Ann Lee, Kyu-Eun Park, Young Joo Park, Do-Joon Yoo, Keun-Young Park, Sue K. PLoS One Research Article INTRODUCTION: Diabetes mellitus (DM) is an important risk factor for endocrine cancers; however, the association with thyroid cancer is not clear. We performed a systematic review and meta-analysis to clarify the association between thyroid cancer and DM. METHODS: We searched MEDLINE, PUBMED and EMBASE databases through July 2012, using search terms related to diabetes mellitus, cancer, and thyroid cancer. We conducted a meta-analysis of the risk of incidence of thyroid cancer from pre-existing diabetes. Of 2,123 titles initially identified, sixteen articles met our inclusion criteria. An additional article was identified from a bibliography. Totally, 14 cohort and 3 case-control studies were selected for the meta-analysis. The risks were estimated using random-effects model and sensitivity test for the studies which reported risk estimates and used different definition of DM. RESULTS: Compared with individuals without DM, the patients with DM were at 1.34-fold higher risk for thyroid cancer (95% CI 1.11–1.63). However, there was heterogeneity in the results (p<0.0001). Sensitivity tests and studies judged to be high quality did not show heterogeneity and DM was associated with higher risk for thyroid cancer in these sub-analyses (both of RRs = 1.18, 95% CIs 1.08–1.28). DM was associated with a 1.38-fold increased risk of thyroid cancer in women (95% CI 1.13–1.67) after sensitivity test. Risk of thyroid cancer in men did not remain significant (RR 1.11, 95% CI 0.80–1.53). CONCLUSIONS: Compared with their non-diabetic counterparts, women with pre-existing DM have an increased risk of thyroid cancer. Public Library of Science 2014-06-13 /pmc/articles/PMC4057085/ /pubmed/24927125 http://dx.doi.org/10.1371/journal.pone.0098135 Text en © 2014 Yeo et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Yeo, Yohwan Ma, Seung-Hyun Hwang, Yunji Horn-Ross, Pamela L. Hsing, Ann Lee, Kyu-Eun Park, Young Joo Park, Do-Joon Yoo, Keun-Young Park, Sue K. Diabetes Mellitus and Risk of Thyroid Cancer: A Meta-Analysis |
title | Diabetes Mellitus and Risk of Thyroid Cancer: A Meta-Analysis |
title_full | Diabetes Mellitus and Risk of Thyroid Cancer: A Meta-Analysis |
title_fullStr | Diabetes Mellitus and Risk of Thyroid Cancer: A Meta-Analysis |
title_full_unstemmed | Diabetes Mellitus and Risk of Thyroid Cancer: A Meta-Analysis |
title_short | Diabetes Mellitus and Risk of Thyroid Cancer: A Meta-Analysis |
title_sort | diabetes mellitus and risk of thyroid cancer: a meta-analysis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057085/ https://www.ncbi.nlm.nih.gov/pubmed/24927125 http://dx.doi.org/10.1371/journal.pone.0098135 |
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