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Silencing of protein kinase D2 induces glioma cell senescence via p53-dependent and -independent pathways

BACKGROUND: Glioblastoma multiforme (GBM) is a highly aggressive tumor of the central nervous system with a dismal prognosis for affected patients. Aberrant protein kinase C (PKC) signaling has been implicated in gliomagenesis, and a member of the PKC-activated protein kinase D (PRKD) family, PRKD2,...

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Detalles Bibliográficos
Autores principales:	Bernhart, Eva, Damm, Sabine, Heffeter, Petra, Wintersperger, Andrea, Asslaber, Martin, Frank, Saša, Hammer, Astrid, Strohmaier, Heimo, DeVaney, Trevor, Mrfka, Manuel, Eder, Hans, Windpassinger, Christian, Ireson, Christopher R., Mischel, Paul S., Berger, Walter, Sattler, Wolfgang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2014
Materias:	Basic and Translational Investigations
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057133/ https://www.ncbi.nlm.nih.gov/pubmed/24463355 http://dx.doi.org/10.1093/neuonc/not303

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