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Genome-Wide Binding of MBD2 Reveals Strong Preference for Highly Methylated Loci
MBD2 is a subunit of the NuRD complex that is postulated to mediate gene repression via recruitment of the complex to methylated DNA. In this study we adopted an MBD2 tagging-approach to study its genome wide binding characteristics. We show that in vivo MBD2 is mainly recruited to CpG island promot...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057170/ https://www.ncbi.nlm.nih.gov/pubmed/24927503 http://dx.doi.org/10.1371/journal.pone.0099603 |