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The effect of excess fluid balance on the mortality rate of surgical patients: a multicenter prospective study
INTRODUCTION: In some studies including small populations of patients undergoing specific surgery, an intraoperative liberal infusion of fluids was associated with increasing morbidity when compared to restrictive strategies. Therefore, to evaluate the role of excessive fluid infusion in a general p...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057181/ https://www.ncbi.nlm.nih.gov/pubmed/24326085 http://dx.doi.org/10.1186/cc13151 |
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author | Silva, João M de Oliveira, Amanda Maria Ribas Rosa Nogueira, Fernando Augusto Mendes Vianna, Pedro Monferrari Monteiro Pereira Filho, Marcos Cruz Dias, Leandro Ferreira Maia, Vivian Paz Leão Neucamp, Cesar de Souza Amendola, Cristina Prata Carmona, Maria José Carvalho Malbouisson, Luiz M Sá |
author_facet | Silva, João M de Oliveira, Amanda Maria Ribas Rosa Nogueira, Fernando Augusto Mendes Vianna, Pedro Monferrari Monteiro Pereira Filho, Marcos Cruz Dias, Leandro Ferreira Maia, Vivian Paz Leão Neucamp, Cesar de Souza Amendola, Cristina Prata Carmona, Maria José Carvalho Malbouisson, Luiz M Sá |
author_sort | Silva, João M |
collection | PubMed |
description | INTRODUCTION: In some studies including small populations of patients undergoing specific surgery, an intraoperative liberal infusion of fluids was associated with increasing morbidity when compared to restrictive strategies. Therefore, to evaluate the role of excessive fluid infusion in a general population with high-risk surgery is very important. The aim of this study was to evaluate the impact of intraoperative fluid balance on the postoperative organ dysfunction, infection and mortality rate. METHODS: We conducted a prospective cohort study during one year in four ICUs from three tertiary hospitals, which included patients aged 18 years or more who required postoperative ICU after undergoing major surgery. Patients who underwent palliative surgery and whose fluid balance could change in outcome were excluded. The calculation of fluid balance was based on preoperative fasting, insensible losses from surgeries and urine output minus fluid replacement intraoperatively. RESULTS: The study included 479 patients. Mean age was 61.2 ± 17.0 years and 8.8% of patients died at the hospital during the study. The median duration of surgery was 4.0 (3.2 to 5.5) h and the value of the Simplified Acute Physiology Score (SAPS) 3 score was 41.8 ± 14.5. Comparing survivors and non-survivors, the intraoperative fluid balance from non-survivors was higher (1,950 (1,400 to 3,400) mL vs. 1,400 (1,000 to 1,600) mL, P <0.001). Patients with fluid balance above 2,000 mL intraoperatively had a longer ICU stay (4.0 (3.0 to 8.0) vs. 3.0 (2.0 to 6.0), P <0.001) and higher incidence of infectious (41.9% vs. 25.9%, P = 0.001), neurological (46.2% vs. 13.2%, P <0.001), cardiovascular (63.2% vs. 39.6%, P <0.001) and respiratory complications (34.3% vs. 11.6%, P <0.001). In multivariate analysis, the fluid balance was an independent factor for death (OR per 100 mL = 1.024; P = 0.006; 95% CI 1.007 to 1.041). CONCLUSIONS: Patients with excessive intraoperative fluid balance have more ICU complications and higher hospital mortality. |
format | Online Article Text |
id | pubmed-4057181 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-40571812014-06-14 The effect of excess fluid balance on the mortality rate of surgical patients: a multicenter prospective study Silva, João M de Oliveira, Amanda Maria Ribas Rosa Nogueira, Fernando Augusto Mendes Vianna, Pedro Monferrari Monteiro Pereira Filho, Marcos Cruz Dias, Leandro Ferreira Maia, Vivian Paz Leão Neucamp, Cesar de Souza Amendola, Cristina Prata Carmona, Maria José Carvalho Malbouisson, Luiz M Sá Crit Care Research INTRODUCTION: In some studies including small populations of patients undergoing specific surgery, an intraoperative liberal infusion of fluids was associated with increasing morbidity when compared to restrictive strategies. Therefore, to evaluate the role of excessive fluid infusion in a general population with high-risk surgery is very important. The aim of this study was to evaluate the impact of intraoperative fluid balance on the postoperative organ dysfunction, infection and mortality rate. METHODS: We conducted a prospective cohort study during one year in four ICUs from three tertiary hospitals, which included patients aged 18 years or more who required postoperative ICU after undergoing major surgery. Patients who underwent palliative surgery and whose fluid balance could change in outcome were excluded. The calculation of fluid balance was based on preoperative fasting, insensible losses from surgeries and urine output minus fluid replacement intraoperatively. RESULTS: The study included 479 patients. Mean age was 61.2 ± 17.0 years and 8.8% of patients died at the hospital during the study. The median duration of surgery was 4.0 (3.2 to 5.5) h and the value of the Simplified Acute Physiology Score (SAPS) 3 score was 41.8 ± 14.5. Comparing survivors and non-survivors, the intraoperative fluid balance from non-survivors was higher (1,950 (1,400 to 3,400) mL vs. 1,400 (1,000 to 1,600) mL, P <0.001). Patients with fluid balance above 2,000 mL intraoperatively had a longer ICU stay (4.0 (3.0 to 8.0) vs. 3.0 (2.0 to 6.0), P <0.001) and higher incidence of infectious (41.9% vs. 25.9%, P = 0.001), neurological (46.2% vs. 13.2%, P <0.001), cardiovascular (63.2% vs. 39.6%, P <0.001) and respiratory complications (34.3% vs. 11.6%, P <0.001). In multivariate analysis, the fluid balance was an independent factor for death (OR per 100 mL = 1.024; P = 0.006; 95% CI 1.007 to 1.041). CONCLUSIONS: Patients with excessive intraoperative fluid balance have more ICU complications and higher hospital mortality. BioMed Central 2013 2013-12-10 /pmc/articles/PMC4057181/ /pubmed/24326085 http://dx.doi.org/10.1186/cc13151 Text en Copyright © 2013 Silva et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Silva, João M de Oliveira, Amanda Maria Ribas Rosa Nogueira, Fernando Augusto Mendes Vianna, Pedro Monferrari Monteiro Pereira Filho, Marcos Cruz Dias, Leandro Ferreira Maia, Vivian Paz Leão Neucamp, Cesar de Souza Amendola, Cristina Prata Carmona, Maria José Carvalho Malbouisson, Luiz M Sá The effect of excess fluid balance on the mortality rate of surgical patients: a multicenter prospective study |
title | The effect of excess fluid balance on the mortality rate of surgical patients: a multicenter prospective study |
title_full | The effect of excess fluid balance on the mortality rate of surgical patients: a multicenter prospective study |
title_fullStr | The effect of excess fluid balance on the mortality rate of surgical patients: a multicenter prospective study |
title_full_unstemmed | The effect of excess fluid balance on the mortality rate of surgical patients: a multicenter prospective study |
title_short | The effect of excess fluid balance on the mortality rate of surgical patients: a multicenter prospective study |
title_sort | effect of excess fluid balance on the mortality rate of surgical patients: a multicenter prospective study |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057181/ https://www.ncbi.nlm.nih.gov/pubmed/24326085 http://dx.doi.org/10.1186/cc13151 |
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