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Lipopolysaccharide infusion enhances dynamic cerebral autoregulation without affecting cerebral oxygen vasoreactivity in healthy volunteers

INTRODUCTION: Sepsis may be associated with disturbances in cerebral oxygen transport and cerebral haemodynamic function, thus rendering the brain particularly susceptible to hypoxia. The purpose of this study was to assess the impact of isocapnic hypoxia and hyperoxia on dynamic cerebral autoregula...

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Autores principales: Berg, Ronan MG, Plovsing, Ronni R, Evans, Kevin A, Christiansen, Claus B, Bailey, Damian M, Holstein-Rathlou, Niels-Henrik, Møller, Kirsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057209/
https://www.ncbi.nlm.nih.gov/pubmed/24131656
http://dx.doi.org/10.1186/cc13062
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author Berg, Ronan MG
Plovsing, Ronni R
Evans, Kevin A
Christiansen, Claus B
Bailey, Damian M
Holstein-Rathlou, Niels-Henrik
Møller, Kirsten
author_facet Berg, Ronan MG
Plovsing, Ronni R
Evans, Kevin A
Christiansen, Claus B
Bailey, Damian M
Holstein-Rathlou, Niels-Henrik
Møller, Kirsten
author_sort Berg, Ronan MG
collection PubMed
description INTRODUCTION: Sepsis may be associated with disturbances in cerebral oxygen transport and cerebral haemodynamic function, thus rendering the brain particularly susceptible to hypoxia. The purpose of this study was to assess the impact of isocapnic hypoxia and hyperoxia on dynamic cerebral autoregulation in a human-experimental model of the systemic inflammatory response during the early stages of sepsis. METHODS: A total of ten healthy volunteers were exposed to acute isocapnic inspiratory hyperoxia (F(I)O(2) = 40%) and hypoxia (F(I)O(2) = 12%) before and after a 4-hour lipopolysaccharide (LPS) infusion (2 ng kg(-1)). Middle cerebral artery blood follow velocity was assessed using transcranial Doppler ultrasound, and dynamic autoregulation was evaluated by transfer function analysis. RESULTS: Transfer function analysis revealed an increase in the phase difference between mean arterial blood pressure and middle cerebral artery blood flow velocity in the low frequency range (0.07–0.20 Hz) after LPS (P<0.01). In contrast, there were no effects of either isocapnic hyperoxia or hypoxia on dynamic autoregulation, and the cerebral oxygen vasoreactivity to both hyperoxia and hypoxia was unaffected by LPS. CONCLUSIONS: The observed increase in phase suggests that dynamic cerebral autoregulation is enhanced after LPS infusion and resistant to any effects of acute hypoxia; this may protect the brain from ischaemia and/or blood–brain barrier damage during the early stages of sepsis.
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spelling pubmed-40572092014-10-23 Lipopolysaccharide infusion enhances dynamic cerebral autoregulation without affecting cerebral oxygen vasoreactivity in healthy volunteers Berg, Ronan MG Plovsing, Ronni R Evans, Kevin A Christiansen, Claus B Bailey, Damian M Holstein-Rathlou, Niels-Henrik Møller, Kirsten Crit Care Research INTRODUCTION: Sepsis may be associated with disturbances in cerebral oxygen transport and cerebral haemodynamic function, thus rendering the brain particularly susceptible to hypoxia. The purpose of this study was to assess the impact of isocapnic hypoxia and hyperoxia on dynamic cerebral autoregulation in a human-experimental model of the systemic inflammatory response during the early stages of sepsis. METHODS: A total of ten healthy volunteers were exposed to acute isocapnic inspiratory hyperoxia (F(I)O(2) = 40%) and hypoxia (F(I)O(2) = 12%) before and after a 4-hour lipopolysaccharide (LPS) infusion (2 ng kg(-1)). Middle cerebral artery blood follow velocity was assessed using transcranial Doppler ultrasound, and dynamic autoregulation was evaluated by transfer function analysis. RESULTS: Transfer function analysis revealed an increase in the phase difference between mean arterial blood pressure and middle cerebral artery blood flow velocity in the low frequency range (0.07–0.20 Hz) after LPS (P<0.01). In contrast, there were no effects of either isocapnic hyperoxia or hypoxia on dynamic autoregulation, and the cerebral oxygen vasoreactivity to both hyperoxia and hypoxia was unaffected by LPS. CONCLUSIONS: The observed increase in phase suggests that dynamic cerebral autoregulation is enhanced after LPS infusion and resistant to any effects of acute hypoxia; this may protect the brain from ischaemia and/or blood–brain barrier damage during the early stages of sepsis. BioMed Central 2013 2013-10-16 /pmc/articles/PMC4057209/ /pubmed/24131656 http://dx.doi.org/10.1186/cc13062 Text en Copyright © 2013 Berg et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Berg, Ronan MG
Plovsing, Ronni R
Evans, Kevin A
Christiansen, Claus B
Bailey, Damian M
Holstein-Rathlou, Niels-Henrik
Møller, Kirsten
Lipopolysaccharide infusion enhances dynamic cerebral autoregulation without affecting cerebral oxygen vasoreactivity in healthy volunteers
title Lipopolysaccharide infusion enhances dynamic cerebral autoregulation without affecting cerebral oxygen vasoreactivity in healthy volunteers
title_full Lipopolysaccharide infusion enhances dynamic cerebral autoregulation without affecting cerebral oxygen vasoreactivity in healthy volunteers
title_fullStr Lipopolysaccharide infusion enhances dynamic cerebral autoregulation without affecting cerebral oxygen vasoreactivity in healthy volunteers
title_full_unstemmed Lipopolysaccharide infusion enhances dynamic cerebral autoregulation without affecting cerebral oxygen vasoreactivity in healthy volunteers
title_short Lipopolysaccharide infusion enhances dynamic cerebral autoregulation without affecting cerebral oxygen vasoreactivity in healthy volunteers
title_sort lipopolysaccharide infusion enhances dynamic cerebral autoregulation without affecting cerebral oxygen vasoreactivity in healthy volunteers
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057209/
https://www.ncbi.nlm.nih.gov/pubmed/24131656
http://dx.doi.org/10.1186/cc13062
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