An Examination of the Relationship between Hotspots and Recombination Associated with Chromosome 21 Nondisjunction

Trisomy 21, resulting in Down Syndrome (DS), is the most common autosomal trisomy among live-born infants and is caused mainly by nondisjunction of chromosome 21 within oocytes. Risk factors for nondisjunction depend on the parental origin and type of meiotic error. For errors in the oocyte, increas...

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Detalles Bibliográficos
Autores principales: Oliver, Tiffany Renee, Middlebrooks, Candace D., Tinker, Stuart W., Allen, Emily Graves, Bean, Lora J. H., Begum, Ferdouse, Feingold, Eleanor, Chowdhury, Reshmi, Cheung, Vivian, Sherman, Stephanie L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057233/
https://www.ncbi.nlm.nih.gov/pubmed/24926858
http://dx.doi.org/10.1371/journal.pone.0099560

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