Cargando…

Development and Evaluation of Small Peptidomimetic Ligands to Protease-Activated Receptor-2 (PAR(2)) through the Use of Lipid Tethering

Protease-activated receptor-2 (PAR(2)) is a G-Protein Coupled Receptor (GPCR) activated by proteolytic cleavage to expose an attached, tethered ligand (SLIGRL). We evaluated the ability for lipid-tethered-peptidomimetics to activate PAR(2) with in vitro physiological and Ca(2+) signaling assays to d...

Descripción completa

Detalles Bibliográficos
Autores principales:	Boitano, Scott, Hoffman, Justin, Tillu, Dipti V., Asiedu, Marina N., Zhang, Zhenyu, Sherwood, Cara L., Wang, Yan, Dong, Xinzhong, Price, Theodore J., Vagner, Josef
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057235/ https://www.ncbi.nlm.nih.gov/pubmed/24927179 http://dx.doi.org/10.1371/journal.pone.0099140

Ejemplares similares

C781, a β-Arrestin Biased Antagonist at Protease-Activated Receptor-2 (PAR2), Displays in vivo Efficacy Against Protease-Induced Pain in Mice
por: Kume, Moeno, et al.
Publicado: (2023)

PAR2 activation in the dura causes acute behavioral responses and priming to glyceryl trinitrate in a mouse migraine model
por: Mason, Bianca N., et al.
Publicado: (2023)

Cathepsin S Signals via PAR2 and Generates a Novel Tethered Ligand Receptor Agonist
por: Elmariah, Sarina B., et al.
Publicado: (2014)

Protease inhibitors and their peptidomimetic derivatives as potential drugs
por: Fear, Georgie, et al.
Publicado: (2007)

Computational study on peptidomimetic inhibitors against SARS-CoV-2 main protease
por: Somboon, Tuanjai, et al.
Publicado: (2021)

Airway epithelial cell exposure to distinct e-cigarette liquid flavorings reveals toxicity thresholds and activation of CFTR by the chocolate flavoring 2,5-dimethypyrazine
por: Sherwood, Cara L., et al.
Publicado: (2016)

Resveratrol engages AMPK to attenuate ERK and mTOR signaling in sensory neurons and inhibits incision-induced acute and chronic pain
por: Tillu, Dipti V, et al.
Publicado: (2012)

Local translation and retrograde axonal transport of CREB regulates IL-6-induced nociceptive plasticity
por: Melemedjian, Ohannes K, et al.
Publicado: (2014)

Adsorption on Ligand-Tethered Nanoparticles
por: Borówko, Małgorzata, et al.
Publicado: (2021)

Development of peptidomimetic ligands of Pro-Leu-Gly-NH(2) as allosteric modulators of the dopamine D(2) receptor
por: Bhagwanth, Swapna, et al.
Publicado: (2013)

Investigation of the Compatibility between Warheads and Peptidomimetic Sequences of Protease Inhibitors—A Comprehensive Reactivity and Selectivity Study
por: Müller, Patrick, et al.
Publicado: (2023)

Peptidomimetics II
por: Lubell, William D
Publicado: (2016)

ParAB Partition Dynamics in Firmicutes: Nucleoid Bound ParA Captures and Tethers ParB-Plasmid Complexes
por: Lioy, Virginia S., et al.
Publicado: (2015)

Peptidomimetic-based antibody surrogate for HER2
por: Zheng, Mengmeng, et al.
Publicado: (2021)

Protease-activated receptor (PAR)-2 is required for PAR-1 signalling in pulmonary fibrosis
por: Lin, Cong, et al.
Publicado: (2015)

Structure-Based Design of Potent Peptidomimetic Inhibitors Covalently Targeting SARS-CoV-2 Papain-like Protease
por: Wang, Qian, et al.
Publicado: (2023)

Neutrophil cathepsin G proteolysis of protease-activated receptor 4 generates a novel, functional tethered ligand
por: Stoller, Michelle L., et al.
Publicado: (2022)

BDNF regulates atypical PKC at spinal synapses to initiate and maintain a centralized chronic pain state
por: Melemedjian, Ohannes K, et al.
Publicado: (2013)

Temporal and sex differences in the role of BDNF/TrkB signaling in hyperalgesic priming in mice and rats
por: Moy, Jamie K., et al.
Publicado: (2018)

Histone 2B Facilitates Plasminogen-Enhanced Endothelial Migration through Protease-Activated Receptor 1 (PAR1) and Protease-Activated Receptor 2 (PAR2)
por: Das, Mitali, et al.
Publicado: (2022)

Peptidomimetics in cancer targeting
por: Gomari, Mohammad Mahmoudi, et al.
Publicado: (2022)

Improved GPCR ligands from nanobody tethering
por: Cheloha, Ross W., et al.
Publicado: (2020)

Lipidated Peptidomimetic Ligand-Functionalized HER2 Targeted Liposome as Nano-Carrier Designed for Doxorubicin Delivery in Cancer Therapy
por: Naik, Himgauri, et al.
Publicado: (2021)

Inhibition of the severe acute respiratory syndrome 3CL protease by peptidomimetic α,β-unsaturated esters
por: Shie, Jiun-Jie, et al.
Publicado: (2005)

Design, synthesis and biological evaluation of covalent peptidomimetic 3CL protease inhibitors containing nitrile moiety
por: Zhu, Mengwei, et al.
Publicado: (2023)

Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
por: Frecer, Vladimir, et al.
Publicado: (2020)

A tethered ligand assay to probe SARS-CoV-2:ACE2 interactions
por: Bauer, Magnus S., et al.
Publicado: (2022)

A tethered ligand assay to probe SARS-CoV-2:ACE2 interactions
por: Bauer, Magnus S., et al.
Publicado: (2022)

Development of Peptidomimetics Targeting IAPs
por: Sharma, Sushil K., et al.
Publicado: (2006)

Using the ribosome to synthesize peptidomimetics
por: Freidinger, Roger M
Publicado: (2009)

Short Cationic Peptidomimetic Antimicrobials
por: Kuppusamy, Rajesh, et al.
Publicado: (2019)

Promising Antibiofilm Activity of Peptidomimetics
por: Gomes Von Borowski, Rafael, et al.
Publicado: (2018)

Peptidomimetics Therapeutics for Retinal Disease
por: Parsons, Dylan E., et al.
Publicado: (2021)

Cell-free Biosynthesis of Peptidomimetics
por: Lee, Kanghun, et al.
Publicado: (2023)

Janus Ligand-Tethered Nanoparticles at Liquid–Liquid Interfaces
por: Borówko, Małgorzata, et al.
Publicado: (2023)

Emerging Roles of Protease-Activated Receptors (PARs) in the Modulation of Synaptic Transmission and Plasticity
por: Price, Rachel, et al.
Publicado: (2021)

Sliding tethered ligands add topological interactions to the toolbox of ligand–receptor design
por: Bauer, Martin, et al.
Publicado: (2015)

Unveiling the Inhibitory Potentials of Peptidomimetic Azanitriles and Pyridyl Esters towards SARS-CoV-2 Main Protease: A Molecular Modelling Investigation
por: Mushebenge, Aganze G., et al.
Publicado: (2023)

Structural Basis of Inhibition Specificities of 3C and 3C-like Proteases by Zinc-coordinating and Peptidomimetic Compounds
por: Lee, Cheng-Chung, et al.
Publicado: (2009)

Predictive value of protease‐activated receptor‐2 (PAR(2)) in cervical cancer metastasis
por: He, Shengnan, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_dh1ckap65l61meno5754o0l4pd