Systemic Sclerosis Immunoglobulin Induces Growth and a Pro-Fibrotic State in Vascular Smooth Muscle Cells through the Epidermal Growth Factor Receptor

OBJECTIVE: It has been suggested that autoantibodies in systemic sclerosis (SSc) may induce the differentiation of cultured fibroblasts into myofibroblasts through platelet-derived growth factor receptor (PDGFR) activation. The present study aims to characterize the effects of SSc IgG on vascular sm...

Descripción completa

Detalles Bibliográficos
Autores principales: Arts, Monique R., Baron, Murray, Chokr, Nidaa, Fritzler, Marvin J., Servant, Marc J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057313/
https://www.ncbi.nlm.nih.gov/pubmed/24927197
http://dx.doi.org/10.1371/journal.pone.0100035

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057313/
https://www.ncbi.nlm.nih.gov/pubmed/24927197
http://dx.doi.org/10.1371/journal.pone.0100035

Ejemplares similares