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Systemic Sclerosis Immunoglobulin Induces Growth and a Pro-Fibrotic State in Vascular Smooth Muscle Cells through the Epidermal Growth Factor Receptor

OBJECTIVE: It has been suggested that autoantibodies in systemic sclerosis (SSc) may induce the differentiation of cultured fibroblasts into myofibroblasts through platelet-derived growth factor receptor (PDGFR) activation. The present study aims to characterize the effects of SSc IgG on vascular sm...

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Detalles Bibliográficos
Autores principales:	Arts, Monique R., Baron, Murray, Chokr, Nidaa, Fritzler, Marvin J., Servant, Marc J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057313/ https://www.ncbi.nlm.nih.gov/pubmed/24927197 http://dx.doi.org/10.1371/journal.pone.0100035

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