TBX2 represses CST6 resulting in uncontrolled legumain activity to sustain breast cancer proliferation: a novel cancer-selective target pathway with therapeutic opportunities.

TBX2 is an oncogenic transcription factor known to drive breast cancer proliferation. We have identified the cysteine protease inhibitor Cystatin 6 (CST6) as a consistently repressed TBX2 target gene, co-repressed through a mechanism involving Early Growth Response 1 (EGR1). Exogenous expression of...

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Detalles Bibliográficos
Autores principales: D'Costa, Zenobia C., Higgins, Catherine, Ong, Chee Wee, Irwin, Gareth W., Boyle, David, McArt, Darragh G., McCloskey, Karen, Buckley, Niamh E., Crawford, Nyree T., Thiagarajan, Lalitha, Murray, James T., Kennedy, Richard D., Mulligan, Karl A., Harkin, D. Paul, Waugh, David J.J., Scott, Chris J., Salto-Tellez, Manuel, Williams, Richard, Mullan, Paul B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057604/
https://www.ncbi.nlm.nih.gov/pubmed/24742492

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