RESCUE OF HIPPO CO-ACTIVATOR YAP1 TRIGGERS DNA DAMAGE-INDUCED APOPTOSIS IN HEMATOLOGICAL CANCERS

Oncogene–induced DNA damage elicits genomic instability in epithelial cancer cells, but apoptosis is blocked through inactivation of the tumor suppressor p53. In hematological cancers, the relevance of ongoing DNA damage and mechanisms by which apoptosis is suppressed are largely unknown. We found p...

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Detalles Bibliográficos
Autores principales: Cottini, Francesca, Hideshima, Teru, Xu, Chunxiao, Sattler, Martin, Dori, Martina, Agnelli, Luca, Hacken, Elisa ten, Bertilaccio, Maria Teresa, Antonini, Elena, Neri, Antonino, Ponzoni, Maurilio, Marcatti, Magda, Richardson, Paul G., Carrasco, Ruben, Kimmelman, Alec C., Wong, Kwok-Kin, Caligaris-Cappio, Federico, Blandino, Giovanni, Kuehl, W. Michael, Anderson, Kenneth C., Tonon, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057660/
https://www.ncbi.nlm.nih.gov/pubmed/24813251
http://dx.doi.org/10.1038/nm.3562

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