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Delivering of Proteins to the Plant Vacuole—An Update
Trafficking of soluble cargo to the vacuole is far from being a closed issue as it can occur by different routes and involve different intermediates. The textbook view of proteins being sorted at the post-Golgi level to the lytic vacuole via the pre-vacuole or to the protein storage vacuole mediated...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Molecular Diversity Preservation International (MDPI)
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057694/ https://www.ncbi.nlm.nih.gov/pubmed/24802873 http://dx.doi.org/10.3390/ijms15057611 |
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author | Pereira, Cláudia Pereira, Susana Pissarra, José |
author_facet | Pereira, Cláudia Pereira, Susana Pissarra, José |
author_sort | Pereira, Cláudia |
collection | PubMed |
description | Trafficking of soluble cargo to the vacuole is far from being a closed issue as it can occur by different routes and involve different intermediates. The textbook view of proteins being sorted at the post-Golgi level to the lytic vacuole via the pre-vacuole or to the protein storage vacuole mediated by dense vesicles is now challenged as novel routes are being disclosed and vacuoles with intermediate characteristics described. The identification of Vacuolar Sorting Determinants is a key signature to understand protein trafficking to the vacuole. Despite the long established vacuolar signals, some others have been described in the last few years, with different properties that can be specific for some cells or some types of vacuoles. There are also reports of proteins having two different vacuolar signals and their significance is questionable: a way to increase the efficiency of the sorting or different sorting depending on the protein roles in a specific context? Along came the idea of differential vacuolar sorting, suggesting a possible specialization of the trafficking pathways according to the type of cell and specific needs. In this review, we show the recent advances in the field and focus on different aspects of protein trafficking to the vacuoles. |
format | Online Article Text |
id | pubmed-4057694 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Molecular Diversity Preservation International (MDPI) |
record_format | MEDLINE/PubMed |
spelling | pubmed-40576942014-06-16 Delivering of Proteins to the Plant Vacuole—An Update Pereira, Cláudia Pereira, Susana Pissarra, José Int J Mol Sci Review Trafficking of soluble cargo to the vacuole is far from being a closed issue as it can occur by different routes and involve different intermediates. The textbook view of proteins being sorted at the post-Golgi level to the lytic vacuole via the pre-vacuole or to the protein storage vacuole mediated by dense vesicles is now challenged as novel routes are being disclosed and vacuoles with intermediate characteristics described. The identification of Vacuolar Sorting Determinants is a key signature to understand protein trafficking to the vacuole. Despite the long established vacuolar signals, some others have been described in the last few years, with different properties that can be specific for some cells or some types of vacuoles. There are also reports of proteins having two different vacuolar signals and their significance is questionable: a way to increase the efficiency of the sorting or different sorting depending on the protein roles in a specific context? Along came the idea of differential vacuolar sorting, suggesting a possible specialization of the trafficking pathways according to the type of cell and specific needs. In this review, we show the recent advances in the field and focus on different aspects of protein trafficking to the vacuoles. Molecular Diversity Preservation International (MDPI) 2014-05-05 /pmc/articles/PMC4057694/ /pubmed/24802873 http://dx.doi.org/10.3390/ijms15057611 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Pereira, Cláudia Pereira, Susana Pissarra, José Delivering of Proteins to the Plant Vacuole—An Update |
title | Delivering of Proteins to the Plant Vacuole—An Update |
title_full | Delivering of Proteins to the Plant Vacuole—An Update |
title_fullStr | Delivering of Proteins to the Plant Vacuole—An Update |
title_full_unstemmed | Delivering of Proteins to the Plant Vacuole—An Update |
title_short | Delivering of Proteins to the Plant Vacuole—An Update |
title_sort | delivering of proteins to the plant vacuole—an update |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057694/ https://www.ncbi.nlm.nih.gov/pubmed/24802873 http://dx.doi.org/10.3390/ijms15057611 |
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