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Delivering of Proteins to the Plant Vacuole—An Update

Trafficking of soluble cargo to the vacuole is far from being a closed issue as it can occur by different routes and involve different intermediates. The textbook view of proteins being sorted at the post-Golgi level to the lytic vacuole via the pre-vacuole or to the protein storage vacuole mediated...

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Detalles Bibliográficos
Autores principales: Pereira, Cláudia, Pereira, Susana, Pissarra, José
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057694/
https://www.ncbi.nlm.nih.gov/pubmed/24802873
http://dx.doi.org/10.3390/ijms15057611
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author Pereira, Cláudia
Pereira, Susana
Pissarra, José
author_facet Pereira, Cláudia
Pereira, Susana
Pissarra, José
author_sort Pereira, Cláudia
collection PubMed
description Trafficking of soluble cargo to the vacuole is far from being a closed issue as it can occur by different routes and involve different intermediates. The textbook view of proteins being sorted at the post-Golgi level to the lytic vacuole via the pre-vacuole or to the protein storage vacuole mediated by dense vesicles is now challenged as novel routes are being disclosed and vacuoles with intermediate characteristics described. The identification of Vacuolar Sorting Determinants is a key signature to understand protein trafficking to the vacuole. Despite the long established vacuolar signals, some others have been described in the last few years, with different properties that can be specific for some cells or some types of vacuoles. There are also reports of proteins having two different vacuolar signals and their significance is questionable: a way to increase the efficiency of the sorting or different sorting depending on the protein roles in a specific context? Along came the idea of differential vacuolar sorting, suggesting a possible specialization of the trafficking pathways according to the type of cell and specific needs. In this review, we show the recent advances in the field and focus on different aspects of protein trafficking to the vacuoles.
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spelling pubmed-40576942014-06-16 Delivering of Proteins to the Plant Vacuole—An Update Pereira, Cláudia Pereira, Susana Pissarra, José Int J Mol Sci Review Trafficking of soluble cargo to the vacuole is far from being a closed issue as it can occur by different routes and involve different intermediates. The textbook view of proteins being sorted at the post-Golgi level to the lytic vacuole via the pre-vacuole or to the protein storage vacuole mediated by dense vesicles is now challenged as novel routes are being disclosed and vacuoles with intermediate characteristics described. The identification of Vacuolar Sorting Determinants is a key signature to understand protein trafficking to the vacuole. Despite the long established vacuolar signals, some others have been described in the last few years, with different properties that can be specific for some cells or some types of vacuoles. There are also reports of proteins having two different vacuolar signals and their significance is questionable: a way to increase the efficiency of the sorting or different sorting depending on the protein roles in a specific context? Along came the idea of differential vacuolar sorting, suggesting a possible specialization of the trafficking pathways according to the type of cell and specific needs. In this review, we show the recent advances in the field and focus on different aspects of protein trafficking to the vacuoles. Molecular Diversity Preservation International (MDPI) 2014-05-05 /pmc/articles/PMC4057694/ /pubmed/24802873 http://dx.doi.org/10.3390/ijms15057611 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Pereira, Cláudia
Pereira, Susana
Pissarra, José
Delivering of Proteins to the Plant Vacuole—An Update
title Delivering of Proteins to the Plant Vacuole—An Update
title_full Delivering of Proteins to the Plant Vacuole—An Update
title_fullStr Delivering of Proteins to the Plant Vacuole—An Update
title_full_unstemmed Delivering of Proteins to the Plant Vacuole—An Update
title_short Delivering of Proteins to the Plant Vacuole—An Update
title_sort delivering of proteins to the plant vacuole—an update
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057694/
https://www.ncbi.nlm.nih.gov/pubmed/24802873
http://dx.doi.org/10.3390/ijms15057611
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