Characterization of Timed Changes in Hepatic Copper Concentrations, Methionine Metabolism, Gene Expression, and Global DNA Methylation in the Jackson Toxic Milk Mouse Model of Wilson Disease

BACKGROUND: Wilson disease (WD) is characterized by hepatic copper accumulation with progressive liver damage to cirrhosis. This study aimed to characterize the toxic milk mouse from The Jackson Laboratory (Bar Harbor, ME, USA) (tx-j) mouse model of WD according to changes over time in hepatic coppe...

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Detalles Bibliográficos
Autores principales: Le, Anh, Shibata, Noreene M., French, Samuel W., Kim, Kyoungmi, Kharbanda, Kusum K., Islam, Mohammad S., LaSalle, Janine M., Halsted, Charles H., Keen, Carl L., Medici, Valentina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057715/
https://www.ncbi.nlm.nih.gov/pubmed/24810691
http://dx.doi.org/10.3390/ijms15058004

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