Apoptotic Death of Cancer Stem Cells for Cancer Therapy

Cancer stem cells (CSCs) play crucial roles in tumor progression, chemo- and radiotherapy resistance, and recurrence. Recent studies on CSCs have advanced understanding of molecular oncology and development of novel therapeutic strategies. This review article updates the hypothesis and paradigm of C...

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Detalles Bibliográficos
Autores principales: He, Ying-Chun, Zhou, Fang-Liang, Shen, Yi, Liao, Duan-Fang, Cao, Deliang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2014
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057734/
https://www.ncbi.nlm.nih.gov/pubmed/24823879
http://dx.doi.org/10.3390/ijms15058335
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author He, Ying-Chun
Zhou, Fang-Liang
Shen, Yi
Liao, Duan-Fang
Cao, Deliang
author_facet He, Ying-Chun
Zhou, Fang-Liang
Shen, Yi
Liao, Duan-Fang
Cao, Deliang
author_sort He, Ying-Chun
collection PubMed
description Cancer stem cells (CSCs) play crucial roles in tumor progression, chemo- and radiotherapy resistance, and recurrence. Recent studies on CSCs have advanced understanding of molecular oncology and development of novel therapeutic strategies. This review article updates the hypothesis and paradigm of CSCs with a focus on major signaling pathways and effectors that regulate CSC apoptosis. Selective CSC apoptotic inducers are introduced and their therapeutic potentials are discussed. These include synthetic and natural compounds, antibodies and recombinant proteins, and oligonucleotides.
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spelling pubmed-40577342014-06-16 Apoptotic Death of Cancer Stem Cells for Cancer Therapy He, Ying-Chun Zhou, Fang-Liang Shen, Yi Liao, Duan-Fang Cao, Deliang Int J Mol Sci Review Cancer stem cells (CSCs) play crucial roles in tumor progression, chemo- and radiotherapy resistance, and recurrence. Recent studies on CSCs have advanced understanding of molecular oncology and development of novel therapeutic strategies. This review article updates the hypothesis and paradigm of CSCs with a focus on major signaling pathways and effectors that regulate CSC apoptosis. Selective CSC apoptotic inducers are introduced and their therapeutic potentials are discussed. These include synthetic and natural compounds, antibodies and recombinant proteins, and oligonucleotides. Molecular Diversity Preservation International (MDPI) 2014-05-12 /pmc/articles/PMC4057734/ /pubmed/24823879 http://dx.doi.org/10.3390/ijms15058335 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
He, Ying-Chun
Zhou, Fang-Liang
Shen, Yi
Liao, Duan-Fang
Cao, Deliang
Apoptotic Death of Cancer Stem Cells for Cancer Therapy
title Apoptotic Death of Cancer Stem Cells for Cancer Therapy
title_full Apoptotic Death of Cancer Stem Cells for Cancer Therapy
title_fullStr Apoptotic Death of Cancer Stem Cells for Cancer Therapy
title_full_unstemmed Apoptotic Death of Cancer Stem Cells for Cancer Therapy
title_short Apoptotic Death of Cancer Stem Cells for Cancer Therapy
title_sort apoptotic death of cancer stem cells for cancer therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057734/
https://www.ncbi.nlm.nih.gov/pubmed/24823879
http://dx.doi.org/10.3390/ijms15058335
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