Cargando…

Alteration of Skin Properties with Autologous Dermal Fibroblasts

Dermal fibroblasts are mesenchymal cells found between the skin epidermis and subcutaneous tissue. They are primarily responsible for synthesizing collagen and glycosaminoglycans; components of extracellular matrix supporting the structural integrity of the skin. Dermal fibroblasts play a pivotal ro...

Descripción completa

Detalles Bibliográficos
Autores principales: Thangapazham, Rajesh L., Darling, Thomas N., Meyerle, Jon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057739/
https://www.ncbi.nlm.nih.gov/pubmed/24828202
http://dx.doi.org/10.3390/ijms15058407
_version_ 1782321022233477120
author Thangapazham, Rajesh L.
Darling, Thomas N.
Meyerle, Jon
author_facet Thangapazham, Rajesh L.
Darling, Thomas N.
Meyerle, Jon
author_sort Thangapazham, Rajesh L.
collection PubMed
description Dermal fibroblasts are mesenchymal cells found between the skin epidermis and subcutaneous tissue. They are primarily responsible for synthesizing collagen and glycosaminoglycans; components of extracellular matrix supporting the structural integrity of the skin. Dermal fibroblasts play a pivotal role in cutaneous wound healing and skin repair. Preclinical studies suggest wider applications of dermal fibroblasts ranging from skin based indications to non-skin tissue regeneration in tendon repair. One clinical application for autologous dermal fibroblasts has been approved by the Food and Drug Administration (FDA) while others are in preclinical development or various stages of regulatory approval. In this context, we outline the role of fibroblasts in wound healing and discuss recent advances and the current development pipeline for cellular therapies using autologous dermal fibroblasts. The microanatomic and phenotypic differences of fibroblasts occupying particular locations within the skin are reviewed, emphasizing the therapeutic relevance of attributes exhibited by subpopulations of fibroblasts. Special focus is provided to fibroblast characteristics that define regional differences in skin, including the thick and hairless skin of the palms and soles as compared to hair-bearing skin. This regional specificity and functional identity of fibroblasts provides another platform for developing regional skin applications such as the induction of hair follicles in bald scalp or alteration of the phenotype of stump skin in amputees to better support their prosthetic devices.
format Online
Article
Text
id pubmed-4057739
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Molecular Diversity Preservation International (MDPI)
record_format MEDLINE/PubMed
spelling pubmed-40577392014-06-16 Alteration of Skin Properties with Autologous Dermal Fibroblasts Thangapazham, Rajesh L. Darling, Thomas N. Meyerle, Jon Int J Mol Sci Review Dermal fibroblasts are mesenchymal cells found between the skin epidermis and subcutaneous tissue. They are primarily responsible for synthesizing collagen and glycosaminoglycans; components of extracellular matrix supporting the structural integrity of the skin. Dermal fibroblasts play a pivotal role in cutaneous wound healing and skin repair. Preclinical studies suggest wider applications of dermal fibroblasts ranging from skin based indications to non-skin tissue regeneration in tendon repair. One clinical application for autologous dermal fibroblasts has been approved by the Food and Drug Administration (FDA) while others are in preclinical development or various stages of regulatory approval. In this context, we outline the role of fibroblasts in wound healing and discuss recent advances and the current development pipeline for cellular therapies using autologous dermal fibroblasts. The microanatomic and phenotypic differences of fibroblasts occupying particular locations within the skin are reviewed, emphasizing the therapeutic relevance of attributes exhibited by subpopulations of fibroblasts. Special focus is provided to fibroblast characteristics that define regional differences in skin, including the thick and hairless skin of the palms and soles as compared to hair-bearing skin. This regional specificity and functional identity of fibroblasts provides another platform for developing regional skin applications such as the induction of hair follicles in bald scalp or alteration of the phenotype of stump skin in amputees to better support their prosthetic devices. Molecular Diversity Preservation International (MDPI) 2014-05-13 /pmc/articles/PMC4057739/ /pubmed/24828202 http://dx.doi.org/10.3390/ijms15058407 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland http://creativecommons.org/licenses/by/3.0/ This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Thangapazham, Rajesh L.
Darling, Thomas N.
Meyerle, Jon
Alteration of Skin Properties with Autologous Dermal Fibroblasts
title Alteration of Skin Properties with Autologous Dermal Fibroblasts
title_full Alteration of Skin Properties with Autologous Dermal Fibroblasts
title_fullStr Alteration of Skin Properties with Autologous Dermal Fibroblasts
title_full_unstemmed Alteration of Skin Properties with Autologous Dermal Fibroblasts
title_short Alteration of Skin Properties with Autologous Dermal Fibroblasts
title_sort alteration of skin properties with autologous dermal fibroblasts
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057739/
https://www.ncbi.nlm.nih.gov/pubmed/24828202
http://dx.doi.org/10.3390/ijms15058407
work_keys_str_mv AT thangapazhamrajeshl alterationofskinpropertieswithautologousdermalfibroblasts
AT darlingthomasn alterationofskinpropertieswithautologousdermalfibroblasts
AT meyerlejon alterationofskinpropertieswithautologousdermalfibroblasts