The Discovery of Potentially Selective Human Neuronal Nitric Oxide Synthase (nNOS) Inhibitors: A Combination of Pharmacophore Modelling, CoMFA, Virtual Screening and Molecular Docking Studies

Neuronal nitric oxide synthase (nNOS) plays an important role in neurotransmission and smooth muscle relaxation. Selective inhibition of nNOS over its other isozymes is highly desirable for the treatment of neurodegenerative diseases to avoid undesirable effects. In this study, we present a workflow...

Descripción completa

Detalles Bibliográficos
Autores principales: Xu, Guanhong, Chen, Yue, Shen, Kun, Wang, Xiuzhen, Li, Fei, He, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Molecular Diversity Preservation International (MDPI) 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057748/
https://www.ncbi.nlm.nih.gov/pubmed/24830557
http://dx.doi.org/10.3390/ijms15058553

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057748/
https://www.ncbi.nlm.nih.gov/pubmed/24830557
http://dx.doi.org/10.3390/ijms15058553

Ejemplares similares