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In Vitro Treatment of Melanoma Brain Metastasis by Simultaneously Targeting the MAPK and PI3K Signaling Pathways

Malignant melanoma is the most lethal form of skin cancer, with a high propensity to metastasize to the brain. More than 60% of melanomas have the BRAF(V600E) mutation, which activates the mitogen-activated protein kinase (MAPK) pathway [1]. In addition, increased PI3K (phosphoinositide 3-kinase) pa...

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Detalles Bibliográficos
Autores principales:	Daphu, Inderjit, Horn, Sindre, Stieber, Daniel, Varughese, Jobin K., Spriet, Endy, Dale, Hege Avsnes, Skaftnesmo, Kai Ove, Bjerkvig, Rolf, Thorsen, Frits
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Molecular Diversity Preservation International (MDPI) 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057758/ https://www.ncbi.nlm.nih.gov/pubmed/24840574 http://dx.doi.org/10.3390/ijms15058773

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