Radiological and pathological characteristics of giant cell tumor of bone treated with denosumab

ABSTRACT: We describe a case of giant cell tumor of the proximal tibia with skip bone metastases of the ipsilateral femur in a 20-year-old man. After the neoadjuvant treatment with denosumab, plain radiographs and computed tomography showed marked osteosclerosis and sclerotic rim formation, and (18)...

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Autores principales: Hakozaki, Michiyuki, Tajino, Takahiro, Yamada, Hitoshi, Hasegawa, Osamu, Tasaki, Kazuhiro, Watanabe, Kazuo, Konno, Shinichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057823/
https://www.ncbi.nlm.nih.gov/pubmed/24906559
http://dx.doi.org/10.1186/1746-1596-9-111
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author Hakozaki, Michiyuki
Tajino, Takahiro
Yamada, Hitoshi
Hasegawa, Osamu
Tasaki, Kazuhiro
Watanabe, Kazuo
Konno, Shinichi
author_facet Hakozaki, Michiyuki
Tajino, Takahiro
Yamada, Hitoshi
Hasegawa, Osamu
Tasaki, Kazuhiro
Watanabe, Kazuo
Konno, Shinichi
author_sort Hakozaki, Michiyuki
collection PubMed
description ABSTRACT: We describe a case of giant cell tumor of the proximal tibia with skip bone metastases of the ipsilateral femur in a 20-year-old man. After the neoadjuvant treatment with denosumab, plain radiographs and computed tomography showed marked osteosclerosis and sclerotic rim formation, and (18)F-FDG PET/CT showed a decreased standardized uptake value, whereas magnetic resonance imaging showed diffuse enhancement of the tumor, nearly the same findings as those at pretreatment. Pathological findings of the surgical specimen after the denosumab treatment showed benign fibrous histiocytoma-like features with complete disappearance of both mononuclear stromal cells and multinuclear osteoclast-like giant cells. VIRTUAL SLIDES: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1090602085125068
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spelling pubmed-40578232014-06-15 Radiological and pathological characteristics of giant cell tumor of bone treated with denosumab Hakozaki, Michiyuki Tajino, Takahiro Yamada, Hitoshi Hasegawa, Osamu Tasaki, Kazuhiro Watanabe, Kazuo Konno, Shinichi Diagn Pathol Letter to the Editor ABSTRACT: We describe a case of giant cell tumor of the proximal tibia with skip bone metastases of the ipsilateral femur in a 20-year-old man. After the neoadjuvant treatment with denosumab, plain radiographs and computed tomography showed marked osteosclerosis and sclerotic rim formation, and (18)F-FDG PET/CT showed a decreased standardized uptake value, whereas magnetic resonance imaging showed diffuse enhancement of the tumor, nearly the same findings as those at pretreatment. Pathological findings of the surgical specimen after the denosumab treatment showed benign fibrous histiocytoma-like features with complete disappearance of both mononuclear stromal cells and multinuclear osteoclast-like giant cells. VIRTUAL SLIDES: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1090602085125068 BioMed Central 2014-06-07 /pmc/articles/PMC4057823/ /pubmed/24906559 http://dx.doi.org/10.1186/1746-1596-9-111 Text en Copyright © 2014 Hakozaki et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Letter to the Editor
Hakozaki, Michiyuki
Tajino, Takahiro
Yamada, Hitoshi
Hasegawa, Osamu
Tasaki, Kazuhiro
Watanabe, Kazuo
Konno, Shinichi
Radiological and pathological characteristics of giant cell tumor of bone treated with denosumab
title Radiological and pathological characteristics of giant cell tumor of bone treated with denosumab
title_full Radiological and pathological characteristics of giant cell tumor of bone treated with denosumab
title_fullStr Radiological and pathological characteristics of giant cell tumor of bone treated with denosumab
title_full_unstemmed Radiological and pathological characteristics of giant cell tumor of bone treated with denosumab
title_short Radiological and pathological characteristics of giant cell tumor of bone treated with denosumab
title_sort radiological and pathological characteristics of giant cell tumor of bone treated with denosumab
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4057823/
https://www.ncbi.nlm.nih.gov/pubmed/24906559
http://dx.doi.org/10.1186/1746-1596-9-111
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