Antitumor activity of the combination of an HSP90 inhibitor and a PI3K/mTOR dual inhibitor against cholangiocarcinoma

The PI3K/Akt/mTOR pathway is overactivated and heat shock protein (HSP) 90 is overexpressed in common cancers. We hypothesized that targeting both pathways can kill intrahepatic cholangiocarcinoma (CCA) cells. HSP90 and PTEN protein expression was evaluated by immunohistochemical staining of samples...

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Detalles Bibliográficos
Autores principales: Chen, Ming-Huang, Chiang, Kun-Chun, Cheng, Chi-Tung, Huang, Shih-Chiang, Chen, Yeng-Yang, Chen, Tsung-Wen, Yeh, Ta-Sen, Jan, Yi-Yin, Wang, Hsi-Ming, Weng, Jiang-Jie, Chang, Peter Mu-Hsin, Liu, Chun-Yu, Li, Chung-Pin, Chao, Yee, Chen, Ming-Han, Huang, Chi-Ying F., Yeh, Chun-Nan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4058012/
https://www.ncbi.nlm.nih.gov/pubmed/24796583

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