Cargando…

FAAH inhibition enhances anandamide mediated anti-tumorigenic effects in non-small cell lung cancer by downregulating the EGF/EGFR pathway

The endocannabinoid anandamide (AEA), a neurotransmitter was shown to have anti-cancer effects. Fatty acid amide hydrolase (FAAH) metabolizes AEA and decreases its anti-tumorigenic activity. In this study, we have analyzed the role of FAAH inhibition in non-small cell lung cancer (NSCLC). We have sh...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ravi, Janani, Sneh, Amita, Shilo, Konstantin, Nasser, Mohd W., Ganju, Ramesh K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2014
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4058020/ https://www.ncbi.nlm.nih.gov/pubmed/24811863

Ejemplares similares

Role of FAAH-Like Anandamide Transporter in Anandamide Inactivation
por: Leung, KwanNok, et al.
Publicado: (2013)

Novel role of cannabinoid receptor 2 in inhibiting EGF/EGFR and IGF-I/IGF-IR pathways in breast cancer
por: Elbaz, Mohamad, et al.
Publicado: (2016)

A catalytically silent FAAH-1 variant drives anandamide transport in neurons
por: Fu, Jin, et al.
Publicado: (2011)

Ketoconazole Inhibits the Cellular Uptake of Anandamide via Inhibition of FAAH at Pharmacologically Relevant Concentrations
por: Björklund, Emmelie, et al.
Publicado: (2014)

Microdeletion in a FAAH pseudogene identified in a patient with high anandamide concentrations and pain insensitivity
por: Habib, Abdella M., et al.
Publicado: (2019)

miR-29b defines the pro-/anti-proliferative effects of S100A7 in breast cancer
por: Zhao, Helong, et al.
Publicado: (2015)

Erratum to: miR-29b defines the pro-/anti-proliferative effects of S100A7 in breast cancer
por: Zhao, Helong, et al.
Publicado: (2015)

A Personal Retrospective: Elevating Anandamide (AEA) by Targeting Fatty Acid Amide Hydrolase (FAAH) and the Fatty Acid Binding Proteins (FABPs)
por: Deutsch, Dale G.
Publicado: (2016)

Full Inhibition of Spinal FAAH Leads to TRPV1-Mediated Analgesic Effects in Neuropathic Rats and Possible Lipoxygenase-Mediated Remodeling of Anandamide Metabolism
por: Starowicz, Katarzyna, et al.
Publicado: (2013)

Targeting the Endocannabinoid System for Neuroprotection: A (19)F-NMR Study of a Selective FAAH Inhibitor Binding with an Anandamide Carrier Protein, HSA
por: Zhuang, Jianqin, et al.
Publicado: (2013)

Anti-Tumorigenic Effect of a Novel Derivative of 2-Hydroxyoleic Acid and the Endocannabinoid Anandamide on Neuroblastoma Cells
por: Golan, Hana, et al.
Publicado: (2022)

Crosstalk between Chemokine Receptor CXCR4 and Cannabinoid Receptor CB(2) in Modulating Breast Cancer Growth and Invasion
por: Nasser, Mohd W., et al.
Publicado: (2011)

C-X-C motif chemokine 12/C-X-C chemokine receptor type 7 signaling regulates breast cancer growth and metastasis by modulating the tumor microenvironment
por: Wani, Nissar Ahmad, et al.
Publicado: (2014)

TRPV2 is a novel biomarker and therapeutic target in triple negative breast cancer
por: Elbaz, Mohamad, et al.
Publicado: (2016)

FAAH inhibitors in the limelight, but regrettably
por: Mallet, Christophe, et al.
Publicado: (2016)

Fatty acid binding protein 5 promotes metastatic potential of triple negative breast cancer cells through enhancing epidermal growth factor receptor stability
por: Powell, Catherine A., et al.
Publicado: (2015)

Cannabinoids as therapeutic agents in cancer: current status and future implications
por: Chakravarti, Bandana, et al.
Publicado: (2014)

FAAH selectively influences placebo effects
por: Peciña, M., et al.
Publicado: (2013)

The endocannabinoid hydrolase FAAH is an allosteric enzyme
por: Dainese, Enrico, et al.
Publicado: (2020)

New insights into the mechanisms of anandamide-induced airway dilation placing its degradation enzyme, FAAH center stage. Commentary on: Simon A, von Einem T, Seidinger A, Matthey M, Bindila L, Wenzel D (2022) The endocannabinoid anandamide is an airway relaxant in health and disease. Nat Commun 13:6941
por: Pfitzer, Gabriele
Publicado: (2023)

Genetic variations in EGF and EGFR and glioblastoma outcome
por: Sjöström, Sara, et al.
Publicado: (2010)

Anandamide Metabolites Protect against Seizures through the TRP Channel Water Witch in Drosophila melanogaster
por: Jacobs, Jack A., et al.
Publicado: (2020)

A polymorphism in the gene of the endocannabinoid-degrading enzyme FAAH (FAAH C385A) is associated with emotional–motivational reactivity
por: Conzelmann, Annette, et al.
Publicado: (2012)

The Endocannabinoid Anandamide Attenuates Acute Respiratory Distress Syndrome by Downregulating miRNA that Target Inflammatory Pathways
por: Sultan, Muthanna, et al.
Publicado: (2021)

EGF Functionalized Polymer-Coated Gold Nanoparticles Promote EGF Photostability and EGFR Internalization for Photothermal Therapy
por: Silva, Catarina Oliveira, et al.
Publicado: (2016)

Anti-carcinogenic activity of anandamide on human glioma in vitro and in vivo
por: MA, CHAO, et al.
Publicado: (2016)

Author Correction: The endocannabinoid hydrolase FAAH is an allosteric enzyme
por: Dainese, Enrico, et al.
Publicado: (2020)

RIZ2 at the crossroad of the EGF/EGFR signaling in colorectal cancer
por: Di Donato, Marzia, et al.
Publicado: (2023)

Possible Anandamide and Palmitoylethanolamide involvement in human stroke
por: Naccarato, Marcello, et al.
Publicado: (2010)

Inactivation of Anandamide Signaling: A Continuing Debate
por: Khairy, Hesham, et al.
Publicado: (2010)

Anandamide inhibits breast tumor-induced angiogenesis
por: Picardi, P, et al.
Publicado: (2014)

Alterations in the Anandamide Metabolism in the Development of Neuropathic Pain
por: Malek, Natalia, et al.
Publicado: (2014)

The endocannabinoid anandamide is an airway relaxant in health and disease
por: Simon, Annika, et al.
Publicado: (2022)

[Retracted] Anti‑carcinogenic activity of anandamide on human glioma in vitro and in vivo
por: Ma, Chao, et al.
Publicado: (2023)

Anti-Bacterial and Anti-Biofilm Activities of Anandamide against the Cariogenic Streptococcus mutans
por: Wolfson, Goldie, et al.
Publicado: (2023)

Molecular Basis for Non-Covalent, Non-Competitive FAAH Inhibition
por: Morgillo, Carmine Marco, et al.
Publicado: (2022)

Molecular basis of FAAH-OUT-associated human pain insensitivity
por: Mikaeili, Hajar, et al.
Publicado: (2023)

FAAH inhibition ameliorates breast cancer in a murine model
por: Tripathy, Mallika, et al.
Publicado: (2023)

The role of EGF-EGFR signalling pathway in hepatocellular carcinoma inflammatory microenvironment
por: Huang, Peixin, et al.
Publicado: (2014)

Folliculin Interacts with Rab35 to Regulate EGF-Induced EGFR Degradation
por: Zheng, Jianchao, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_un0r2vobcu9sk706bgeegdool4