IGF-1R, a target of let-7b, mediates crosstalk between IRS-2/Akt and MAPK pathways to promote proliferation of oral squamous cell carcinoma

Insulin-like growth factor (IGF) signaling is involved in oral squamous cell carcinoma (OSCC), but IGF-1 receptor (IGF-1R)-mediated intricate regulatory networks among molecular interactions and signalling path ways in OSCC remain unclear. Here, we found that overexpression of IGF-1R and insulin rec...

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Detalles Bibliográficos
Autores principales: Gao, Ling, Wang, Xiaolong, Wang, Xiaofei, Zhang, Linmei, Qiang, Cui, Chang, Su'e, Ren, Wenhao, Li, Shaoming, Yang, Yang, Tong, Dongdong, Chen, Cheng, Li, Zongfang, Song, Tusheng, Zhi, Keqian, Huang, Chen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4058027/
https://www.ncbi.nlm.nih.gov/pubmed/24810113

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