CXC and CC Chemokines as Angiogenic Modulators in Nonhaematological Tumors

Chemokines are a superfamily of structurally homologous heparin-binding proteins that includes potent inducers and inhibitors of angiogenesis. The imbalance between angiogenic and angiostatic chemokine activities can lead to abnormalities, such as chronic inflammation, dysplastic transformation, and...

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Detalles Bibliográficos
Autores principales: Santoni, Matteo, Bracarda, Sergio, Nabissi, Massimo, Massari, Francesco, Conti, Alessandro, Bria, Emilio, Tortora, Giampaolo, Santoni, Giorgio, Cascinu, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4058128/
https://www.ncbi.nlm.nih.gov/pubmed/24971349
http://dx.doi.org/10.1155/2014/768758
Descripción
Sumario:Chemokines are a superfamily of structurally homologous heparin-binding proteins that includes potent inducers and inhibitors of angiogenesis. The imbalance between angiogenic and angiostatic chemokine activities can lead to abnormalities, such as chronic inflammation, dysplastic transformation, and even tumor development and spreading. In this review, we summarize the current literature regarding the role of chemokines as modulators of tumor angiogenesis and their potential role as therapeutic targets in patients with nonhaematological tumors.

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