CXC and CC Chemokines as Angiogenic Modulators in Nonhaematological Tumors

Chemokines are a superfamily of structurally homologous heparin-binding proteins that includes potent inducers and inhibitors of angiogenesis. The imbalance between angiogenic and angiostatic chemokine activities can lead to abnormalities, such as chronic inflammation, dysplastic transformation, and...

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Autores principales: Santoni, Matteo, Bracarda, Sergio, Nabissi, Massimo, Massari, Francesco, Conti, Alessandro, Bria, Emilio, Tortora, Giampaolo, Santoni, Giorgio, Cascinu, Stefano
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4058128/
https://www.ncbi.nlm.nih.gov/pubmed/24971349
http://dx.doi.org/10.1155/2014/768758
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author Santoni, Matteo
Bracarda, Sergio
Nabissi, Massimo
Massari, Francesco
Conti, Alessandro
Bria, Emilio
Tortora, Giampaolo
Santoni, Giorgio
Cascinu, Stefano
author_facet Santoni, Matteo
Bracarda, Sergio
Nabissi, Massimo
Massari, Francesco
Conti, Alessandro
Bria, Emilio
Tortora, Giampaolo
Santoni, Giorgio
Cascinu, Stefano
author_sort Santoni, Matteo
collection PubMed
description Chemokines are a superfamily of structurally homologous heparin-binding proteins that includes potent inducers and inhibitors of angiogenesis. The imbalance between angiogenic and angiostatic chemokine activities can lead to abnormalities, such as chronic inflammation, dysplastic transformation, and even tumor development and spreading. In this review, we summarize the current literature regarding the role of chemokines as modulators of tumor angiogenesis and their potential role as therapeutic targets in patients with nonhaematological tumors.
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spelling pubmed-40581282014-06-26 CXC and CC Chemokines as Angiogenic Modulators in Nonhaematological Tumors Santoni, Matteo Bracarda, Sergio Nabissi, Massimo Massari, Francesco Conti, Alessandro Bria, Emilio Tortora, Giampaolo Santoni, Giorgio Cascinu, Stefano Biomed Res Int Review Article Chemokines are a superfamily of structurally homologous heparin-binding proteins that includes potent inducers and inhibitors of angiogenesis. The imbalance between angiogenic and angiostatic chemokine activities can lead to abnormalities, such as chronic inflammation, dysplastic transformation, and even tumor development and spreading. In this review, we summarize the current literature regarding the role of chemokines as modulators of tumor angiogenesis and their potential role as therapeutic targets in patients with nonhaematological tumors. Hindawi Publishing Corporation 2014 2014-05-29 /pmc/articles/PMC4058128/ /pubmed/24971349 http://dx.doi.org/10.1155/2014/768758 Text en Copyright © 2014 Matteo Santoni et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Santoni, Matteo
Bracarda, Sergio
Nabissi, Massimo
Massari, Francesco
Conti, Alessandro
Bria, Emilio
Tortora, Giampaolo
Santoni, Giorgio
Cascinu, Stefano
CXC and CC Chemokines as Angiogenic Modulators in Nonhaematological Tumors
title CXC and CC Chemokines as Angiogenic Modulators in Nonhaematological Tumors
title_full CXC and CC Chemokines as Angiogenic Modulators in Nonhaematological Tumors
title_fullStr CXC and CC Chemokines as Angiogenic Modulators in Nonhaematological Tumors
title_full_unstemmed CXC and CC Chemokines as Angiogenic Modulators in Nonhaematological Tumors
title_short CXC and CC Chemokines as Angiogenic Modulators in Nonhaematological Tumors
title_sort cxc and cc chemokines as angiogenic modulators in nonhaematological tumors
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4058128/
https://www.ncbi.nlm.nih.gov/pubmed/24971349
http://dx.doi.org/10.1155/2014/768758
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