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Essential Oils Loaded in Nanosystems: A Developing Strategy for a Successful Therapeutic Approach

Essential oils are complex blends of a variety of volatile molecules such as terpenoids, phenol-derived aromatic components, and aliphatic components having a strong interest in pharmaceutical, sanitary, cosmetic, agricultural, and food industries. Since the middle ages, essential oils have been wid...

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Autores principales: Bilia, Anna Rita, Guccione, Clizia, Isacchi, Benedetta, Righeschi, Chiara, Firenzuoli, Fabio, Bergonzi, Maria Camilla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4058161/
https://www.ncbi.nlm.nih.gov/pubmed/24971152
http://dx.doi.org/10.1155/2014/651593
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author Bilia, Anna Rita
Guccione, Clizia
Isacchi, Benedetta
Righeschi, Chiara
Firenzuoli, Fabio
Bergonzi, Maria Camilla
author_facet Bilia, Anna Rita
Guccione, Clizia
Isacchi, Benedetta
Righeschi, Chiara
Firenzuoli, Fabio
Bergonzi, Maria Camilla
author_sort Bilia, Anna Rita
collection PubMed
description Essential oils are complex blends of a variety of volatile molecules such as terpenoids, phenol-derived aromatic components, and aliphatic components having a strong interest in pharmaceutical, sanitary, cosmetic, agricultural, and food industries. Since the middle ages, essential oils have been widely used for bactericidal, virucidal, fungicidal, antiparasitical, insecticidal, and other medicinal properties such as analgesic, sedative, anti-inflammatory, spasmolytic, and locally anaesthetic remedies. In this review their nanoencapsulation in drug delivery systems has been proposed for their capability of decreasing volatility, improving the stability, water solubility, and efficacy of essential oil-based formulations, by maintenance of therapeutic efficacy. Two categories of nanocarriers can be proposed: polymeric nanoparticulate formulations, extensively studied with significant improvement of the essential oil antimicrobial activity, and lipid carriers, including liposomes, solid lipid nanoparticles, nanostructured lipid particles, and nano- and microemulsions. Furthermore, molecular complexes such as cyclodextrin inclusion complexes also represent a valid strategy to increase water solubility and stability and bioavailability and decrease volatility of essential oils.
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spelling pubmed-40581612014-06-26 Essential Oils Loaded in Nanosystems: A Developing Strategy for a Successful Therapeutic Approach Bilia, Anna Rita Guccione, Clizia Isacchi, Benedetta Righeschi, Chiara Firenzuoli, Fabio Bergonzi, Maria Camilla Evid Based Complement Alternat Med Review Article Essential oils are complex blends of a variety of volatile molecules such as terpenoids, phenol-derived aromatic components, and aliphatic components having a strong interest in pharmaceutical, sanitary, cosmetic, agricultural, and food industries. Since the middle ages, essential oils have been widely used for bactericidal, virucidal, fungicidal, antiparasitical, insecticidal, and other medicinal properties such as analgesic, sedative, anti-inflammatory, spasmolytic, and locally anaesthetic remedies. In this review their nanoencapsulation in drug delivery systems has been proposed for their capability of decreasing volatility, improving the stability, water solubility, and efficacy of essential oil-based formulations, by maintenance of therapeutic efficacy. Two categories of nanocarriers can be proposed: polymeric nanoparticulate formulations, extensively studied with significant improvement of the essential oil antimicrobial activity, and lipid carriers, including liposomes, solid lipid nanoparticles, nanostructured lipid particles, and nano- and microemulsions. Furthermore, molecular complexes such as cyclodextrin inclusion complexes also represent a valid strategy to increase water solubility and stability and bioavailability and decrease volatility of essential oils. Hindawi Publishing Corporation 2014 2014-05-29 /pmc/articles/PMC4058161/ /pubmed/24971152 http://dx.doi.org/10.1155/2014/651593 Text en Copyright © 2014 Anna Rita Bilia et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Bilia, Anna Rita
Guccione, Clizia
Isacchi, Benedetta
Righeschi, Chiara
Firenzuoli, Fabio
Bergonzi, Maria Camilla
Essential Oils Loaded in Nanosystems: A Developing Strategy for a Successful Therapeutic Approach
title Essential Oils Loaded in Nanosystems: A Developing Strategy for a Successful Therapeutic Approach
title_full Essential Oils Loaded in Nanosystems: A Developing Strategy for a Successful Therapeutic Approach
title_fullStr Essential Oils Loaded in Nanosystems: A Developing Strategy for a Successful Therapeutic Approach
title_full_unstemmed Essential Oils Loaded in Nanosystems: A Developing Strategy for a Successful Therapeutic Approach
title_short Essential Oils Loaded in Nanosystems: A Developing Strategy for a Successful Therapeutic Approach
title_sort essential oils loaded in nanosystems: a developing strategy for a successful therapeutic approach
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4058161/
https://www.ncbi.nlm.nih.gov/pubmed/24971152
http://dx.doi.org/10.1155/2014/651593
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