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Card-placing test in amnestic mild cognitive impairment and its neural correlates

BACKGROUD: We investigated anatomical correlates of the card-placing test (CPT) in patients with amnestic mild cognitive impairment (aMCI). METHODS: Fifteen aMCI patients underwent part A and part B of the CPT and FDG-PET. The CPT scores and MMSE scores of 29 cognitively normal people were used for...

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Autores principales: Lee, Seong-Joon, An, Young-Sil, Lim, Tae Sung, Moon, So Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4058449/
https://www.ncbi.nlm.nih.gov/pubmed/24906452
http://dx.doi.org/10.1186/1471-2377-14-123
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author Lee, Seong-Joon
An, Young-Sil
Lim, Tae Sung
Moon, So Young
author_facet Lee, Seong-Joon
An, Young-Sil
Lim, Tae Sung
Moon, So Young
author_sort Lee, Seong-Joon
collection PubMed
description BACKGROUD: We investigated anatomical correlates of the card-placing test (CPT) in patients with amnestic mild cognitive impairment (aMCI). METHODS: Fifteen aMCI patients underwent part A and part B of the CPT and FDG-PET. The CPT scores and MMSE scores of 29 cognitively normal people were used for comparison. Statistical parametric mapping (SPM) correlation analysis was used to extract the regions whose changes in regional cerebral metabolism correlated significantly with part A and B of the CPT with adjustment of age, education and sex of patients. RESULTS: The aMCI patients had significantly lower MMSE scores (26.0 ± 2.0 vs. 28.2 ± 1.4, p < 0.001), CPT A (25.5 ± 3.5 vs. 27.7 ± 2.7, p = 0.026) and CPT B scores (16.3 ± 4.4 vs. 19.7 ± 3.7, p = 0.011) compared to the normal population. The test scores of part B of the CPT correlated well with hypometabolism of the posterior cingulate gyrus and precuneus. CONCLUSIONS: This study suggests that the CPT B may reflect the functional status of the posterior cingulate gyrus in patients with aMCI.
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spelling pubmed-40584492014-06-17 Card-placing test in amnestic mild cognitive impairment and its neural correlates Lee, Seong-Joon An, Young-Sil Lim, Tae Sung Moon, So Young BMC Neurol Research Article BACKGROUD: We investigated anatomical correlates of the card-placing test (CPT) in patients with amnestic mild cognitive impairment (aMCI). METHODS: Fifteen aMCI patients underwent part A and part B of the CPT and FDG-PET. The CPT scores and MMSE scores of 29 cognitively normal people were used for comparison. Statistical parametric mapping (SPM) correlation analysis was used to extract the regions whose changes in regional cerebral metabolism correlated significantly with part A and B of the CPT with adjustment of age, education and sex of patients. RESULTS: The aMCI patients had significantly lower MMSE scores (26.0 ± 2.0 vs. 28.2 ± 1.4, p < 0.001), CPT A (25.5 ± 3.5 vs. 27.7 ± 2.7, p = 0.026) and CPT B scores (16.3 ± 4.4 vs. 19.7 ± 3.7, p = 0.011) compared to the normal population. The test scores of part B of the CPT correlated well with hypometabolism of the posterior cingulate gyrus and precuneus. CONCLUSIONS: This study suggests that the CPT B may reflect the functional status of the posterior cingulate gyrus in patients with aMCI. BioMed Central 2014-06-06 /pmc/articles/PMC4058449/ /pubmed/24906452 http://dx.doi.org/10.1186/1471-2377-14-123 Text en Copyright © 2014 Lee et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Lee, Seong-Joon
An, Young-Sil
Lim, Tae Sung
Moon, So Young
Card-placing test in amnestic mild cognitive impairment and its neural correlates
title Card-placing test in amnestic mild cognitive impairment and its neural correlates
title_full Card-placing test in amnestic mild cognitive impairment and its neural correlates
title_fullStr Card-placing test in amnestic mild cognitive impairment and its neural correlates
title_full_unstemmed Card-placing test in amnestic mild cognitive impairment and its neural correlates
title_short Card-placing test in amnestic mild cognitive impairment and its neural correlates
title_sort card-placing test in amnestic mild cognitive impairment and its neural correlates
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4058449/
https://www.ncbi.nlm.nih.gov/pubmed/24906452
http://dx.doi.org/10.1186/1471-2377-14-123
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