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Card-placing test in amnestic mild cognitive impairment and its neural correlates
BACKGROUD: We investigated anatomical correlates of the card-placing test (CPT) in patients with amnestic mild cognitive impairment (aMCI). METHODS: Fifteen aMCI patients underwent part A and part B of the CPT and FDG-PET. The CPT scores and MMSE scores of 29 cognitively normal people were used for...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4058449/ https://www.ncbi.nlm.nih.gov/pubmed/24906452 http://dx.doi.org/10.1186/1471-2377-14-123 |
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author | Lee, Seong-Joon An, Young-Sil Lim, Tae Sung Moon, So Young |
author_facet | Lee, Seong-Joon An, Young-Sil Lim, Tae Sung Moon, So Young |
author_sort | Lee, Seong-Joon |
collection | PubMed |
description | BACKGROUD: We investigated anatomical correlates of the card-placing test (CPT) in patients with amnestic mild cognitive impairment (aMCI). METHODS: Fifteen aMCI patients underwent part A and part B of the CPT and FDG-PET. The CPT scores and MMSE scores of 29 cognitively normal people were used for comparison. Statistical parametric mapping (SPM) correlation analysis was used to extract the regions whose changes in regional cerebral metabolism correlated significantly with part A and B of the CPT with adjustment of age, education and sex of patients. RESULTS: The aMCI patients had significantly lower MMSE scores (26.0 ± 2.0 vs. 28.2 ± 1.4, p < 0.001), CPT A (25.5 ± 3.5 vs. 27.7 ± 2.7, p = 0.026) and CPT B scores (16.3 ± 4.4 vs. 19.7 ± 3.7, p = 0.011) compared to the normal population. The test scores of part B of the CPT correlated well with hypometabolism of the posterior cingulate gyrus and precuneus. CONCLUSIONS: This study suggests that the CPT B may reflect the functional status of the posterior cingulate gyrus in patients with aMCI. |
format | Online Article Text |
id | pubmed-4058449 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-40584492014-06-17 Card-placing test in amnestic mild cognitive impairment and its neural correlates Lee, Seong-Joon An, Young-Sil Lim, Tae Sung Moon, So Young BMC Neurol Research Article BACKGROUD: We investigated anatomical correlates of the card-placing test (CPT) in patients with amnestic mild cognitive impairment (aMCI). METHODS: Fifteen aMCI patients underwent part A and part B of the CPT and FDG-PET. The CPT scores and MMSE scores of 29 cognitively normal people were used for comparison. Statistical parametric mapping (SPM) correlation analysis was used to extract the regions whose changes in regional cerebral metabolism correlated significantly with part A and B of the CPT with adjustment of age, education and sex of patients. RESULTS: The aMCI patients had significantly lower MMSE scores (26.0 ± 2.0 vs. 28.2 ± 1.4, p < 0.001), CPT A (25.5 ± 3.5 vs. 27.7 ± 2.7, p = 0.026) and CPT B scores (16.3 ± 4.4 vs. 19.7 ± 3.7, p = 0.011) compared to the normal population. The test scores of part B of the CPT correlated well with hypometabolism of the posterior cingulate gyrus and precuneus. CONCLUSIONS: This study suggests that the CPT B may reflect the functional status of the posterior cingulate gyrus in patients with aMCI. BioMed Central 2014-06-06 /pmc/articles/PMC4058449/ /pubmed/24906452 http://dx.doi.org/10.1186/1471-2377-14-123 Text en Copyright © 2014 Lee et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Lee, Seong-Joon An, Young-Sil Lim, Tae Sung Moon, So Young Card-placing test in amnestic mild cognitive impairment and its neural correlates |
title | Card-placing test in amnestic mild cognitive impairment and its neural correlates |
title_full | Card-placing test in amnestic mild cognitive impairment and its neural correlates |
title_fullStr | Card-placing test in amnestic mild cognitive impairment and its neural correlates |
title_full_unstemmed | Card-placing test in amnestic mild cognitive impairment and its neural correlates |
title_short | Card-placing test in amnestic mild cognitive impairment and its neural correlates |
title_sort | card-placing test in amnestic mild cognitive impairment and its neural correlates |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4058449/ https://www.ncbi.nlm.nih.gov/pubmed/24906452 http://dx.doi.org/10.1186/1471-2377-14-123 |
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