Mitochondrial DNA disease—molecular insights and potential routes to a cure

Mitochondrial DNA diseases are common neurological conditions caused by mutations in the mitochondrial genome or nuclear genes responsible for its maintenance. Current treatments for these disorders are focussed on the management of the symptoms, rather than the correction of biochemical defects cau...

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Detalles Bibliográficos
Autores principales: Russell, Oliver, Turnbull, Doug
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Academic Press 2014
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4058519/
https://www.ncbi.nlm.nih.gov/pubmed/24675282
http://dx.doi.org/10.1016/j.yexcr.2014.03.012
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author Russell, Oliver
Turnbull, Doug
author_facet Russell, Oliver
Turnbull, Doug
author_sort Russell, Oliver
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description Mitochondrial DNA diseases are common neurological conditions caused by mutations in the mitochondrial genome or nuclear genes responsible for its maintenance. Current treatments for these disorders are focussed on the management of the symptoms, rather than the correction of biochemical defects caused by the mutation. This review focuses on the molecular effects of mutations, the symptoms they cause and current work focusing on the development of targeted treatments for mitochondrial DNA disease.
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spelling pubmed-40585192014-07-01 Mitochondrial DNA disease—molecular insights and potential routes to a cure Russell, Oliver Turnbull, Doug Exp Cell Res Review Article Mitochondrial DNA diseases are common neurological conditions caused by mutations in the mitochondrial genome or nuclear genes responsible for its maintenance. Current treatments for these disorders are focussed on the management of the symptoms, rather than the correction of biochemical defects caused by the mutation. This review focuses on the molecular effects of mutations, the symptoms they cause and current work focusing on the development of targeted treatments for mitochondrial DNA disease. Academic Press 2014-07-01 /pmc/articles/PMC4058519/ /pubmed/24675282 http://dx.doi.org/10.1016/j.yexcr.2014.03.012 Text en © 2014 The Authors http://creativecommons.org/licenses/by/3.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review Article
Russell, Oliver
Turnbull, Doug
Mitochondrial DNA disease—molecular insights and potential routes to a cure
title Mitochondrial DNA disease—molecular insights and potential routes to a cure
title_full Mitochondrial DNA disease—molecular insights and potential routes to a cure
title_fullStr Mitochondrial DNA disease—molecular insights and potential routes to a cure
title_full_unstemmed Mitochondrial DNA disease—molecular insights and potential routes to a cure
title_short Mitochondrial DNA disease—molecular insights and potential routes to a cure
title_sort mitochondrial dna disease—molecular insights and potential routes to a cure
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4058519/
https://www.ncbi.nlm.nih.gov/pubmed/24675282
http://dx.doi.org/10.1016/j.yexcr.2014.03.012
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