Cargando…

Determination of Residual Nonsteroidal Anti-Inflammatory Drugs in Aqueous Sample Using Magnetic Nanoparticles Modified with Cetyltrimethylammonium Bromide by High Performance Liquid Chromatography

A simple and sensitive solid-phase extraction method for separation and preconcentration of trace amount of four nonsteroidal anti-inflammatory drugs (naproxen, indomethacin, diclofenac, and ibuprofen) using Fe(3)O(4) magnetic nanoparticles modified with cetyltrimethylammonium bromide has been devel...

Descripción completa

Detalles Bibliográficos
Autores principales: Khoeini Sharifabadi, Malihe, Saber-Tehrani, Mohammad, Waqif Husain, Syed, Mehdinia, Ali, Aberoomand-Azar, Parviz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4058801/
https://www.ncbi.nlm.nih.gov/pubmed/24982923
http://dx.doi.org/10.1155/2014/127835
_version_ 1782321169839423488
author Khoeini Sharifabadi, Malihe
Saber-Tehrani, Mohammad
Waqif Husain, Syed
Mehdinia, Ali
Aberoomand-Azar, Parviz
author_facet Khoeini Sharifabadi, Malihe
Saber-Tehrani, Mohammad
Waqif Husain, Syed
Mehdinia, Ali
Aberoomand-Azar, Parviz
author_sort Khoeini Sharifabadi, Malihe
collection PubMed
description A simple and sensitive solid-phase extraction method for separation and preconcentration of trace amount of four nonsteroidal anti-inflammatory drugs (naproxen, indomethacin, diclofenac, and ibuprofen) using Fe(3)O(4) magnetic nanoparticles modified with cetyltrimethylammonium bromide has been developed. For this purpose, the surface of MNP(s) was modified with cetyltrimethylammonium bromide (CTAB) as a cationic surfactant. Effects of different parameters influencing the extraction efficiency of drugs including the pH, amount of salt, shaking time, eluent type, the volume of solvent, amount of adsorbent, sample volume, and the time of desorption were investigated and optimized. Methanol has been used as desorption solvent and the extracts were analysed on a reversed-phase octadecyl silica column using 0.02 M phosphate-buffer (pH = 6.02) acetonitrile (65 : 35 v/v) as the mobile phase and the effluents were measured at 202 nm with ultraviolet detector. The relative standard deviation (RSD%) of the method was investigated at three concentrations (25, 50, and 200 ng/mL) and was in the range of 3.98–9.83% (n = 6) for 50 ng/mL. The calibration curves obtained for studied drugs show reasonable linearity (R (2) > 0.99) and the limit of detection (LOD(s)) ranged between 2 and 7 ng/mL. Finally, the proposed method has been effectively employed in extraction and determination of the drugs in biological and environmental samples.
format Online
Article
Text
id pubmed-4058801
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-40588012014-06-30 Determination of Residual Nonsteroidal Anti-Inflammatory Drugs in Aqueous Sample Using Magnetic Nanoparticles Modified with Cetyltrimethylammonium Bromide by High Performance Liquid Chromatography Khoeini Sharifabadi, Malihe Saber-Tehrani, Mohammad Waqif Husain, Syed Mehdinia, Ali Aberoomand-Azar, Parviz ScientificWorldJournal Research Article A simple and sensitive solid-phase extraction method for separation and preconcentration of trace amount of four nonsteroidal anti-inflammatory drugs (naproxen, indomethacin, diclofenac, and ibuprofen) using Fe(3)O(4) magnetic nanoparticles modified with cetyltrimethylammonium bromide has been developed. For this purpose, the surface of MNP(s) was modified with cetyltrimethylammonium bromide (CTAB) as a cationic surfactant. Effects of different parameters influencing the extraction efficiency of drugs including the pH, amount of salt, shaking time, eluent type, the volume of solvent, amount of adsorbent, sample volume, and the time of desorption were investigated and optimized. Methanol has been used as desorption solvent and the extracts were analysed on a reversed-phase octadecyl silica column using 0.02 M phosphate-buffer (pH = 6.02) acetonitrile (65 : 35 v/v) as the mobile phase and the effluents were measured at 202 nm with ultraviolet detector. The relative standard deviation (RSD%) of the method was investigated at three concentrations (25, 50, and 200 ng/mL) and was in the range of 3.98–9.83% (n = 6) for 50 ng/mL. The calibration curves obtained for studied drugs show reasonable linearity (R (2) > 0.99) and the limit of detection (LOD(s)) ranged between 2 and 7 ng/mL. Finally, the proposed method has been effectively employed in extraction and determination of the drugs in biological and environmental samples. Hindawi Publishing Corporation 2014 2014-06-01 /pmc/articles/PMC4058801/ /pubmed/24982923 http://dx.doi.org/10.1155/2014/127835 Text en Copyright © 2014 Malihe Khoeini Sharifabadi et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Khoeini Sharifabadi, Malihe
Saber-Tehrani, Mohammad
Waqif Husain, Syed
Mehdinia, Ali
Aberoomand-Azar, Parviz
Determination of Residual Nonsteroidal Anti-Inflammatory Drugs in Aqueous Sample Using Magnetic Nanoparticles Modified with Cetyltrimethylammonium Bromide by High Performance Liquid Chromatography
title Determination of Residual Nonsteroidal Anti-Inflammatory Drugs in Aqueous Sample Using Magnetic Nanoparticles Modified with Cetyltrimethylammonium Bromide by High Performance Liquid Chromatography
title_full Determination of Residual Nonsteroidal Anti-Inflammatory Drugs in Aqueous Sample Using Magnetic Nanoparticles Modified with Cetyltrimethylammonium Bromide by High Performance Liquid Chromatography
title_fullStr Determination of Residual Nonsteroidal Anti-Inflammatory Drugs in Aqueous Sample Using Magnetic Nanoparticles Modified with Cetyltrimethylammonium Bromide by High Performance Liquid Chromatography
title_full_unstemmed Determination of Residual Nonsteroidal Anti-Inflammatory Drugs in Aqueous Sample Using Magnetic Nanoparticles Modified with Cetyltrimethylammonium Bromide by High Performance Liquid Chromatography
title_short Determination of Residual Nonsteroidal Anti-Inflammatory Drugs in Aqueous Sample Using Magnetic Nanoparticles Modified with Cetyltrimethylammonium Bromide by High Performance Liquid Chromatography
title_sort determination of residual nonsteroidal anti-inflammatory drugs in aqueous sample using magnetic nanoparticles modified with cetyltrimethylammonium bromide by high performance liquid chromatography
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4058801/
https://www.ncbi.nlm.nih.gov/pubmed/24982923
http://dx.doi.org/10.1155/2014/127835
work_keys_str_mv AT khoeinisharifabadimalihe determinationofresidualnonsteroidalantiinflammatorydrugsinaqueoussampleusingmagneticnanoparticlesmodifiedwithcetyltrimethylammoniumbromidebyhighperformanceliquidchromatography
AT sabertehranimohammad determinationofresidualnonsteroidalantiinflammatorydrugsinaqueoussampleusingmagneticnanoparticlesmodifiedwithcetyltrimethylammoniumbromidebyhighperformanceliquidchromatography
AT waqifhusainsyed determinationofresidualnonsteroidalantiinflammatorydrugsinaqueoussampleusingmagneticnanoparticlesmodifiedwithcetyltrimethylammoniumbromidebyhighperformanceliquidchromatography
AT mehdiniaali determinationofresidualnonsteroidalantiinflammatorydrugsinaqueoussampleusingmagneticnanoparticlesmodifiedwithcetyltrimethylammoniumbromidebyhighperformanceliquidchromatography
AT aberoomandazarparviz determinationofresidualnonsteroidalantiinflammatorydrugsinaqueoussampleusingmagneticnanoparticlesmodifiedwithcetyltrimethylammoniumbromidebyhighperformanceliquidchromatography