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Inferring gene ontologies from pairwise similarity data
Motivation: 1. analyze a full matrix of gene–gene pairwise similarities from -omics data; 2. infer true hierarchical structure in these data rather than enforcing hierarchy as a computational artifact; and 3. respect biological pleiotropy, by which a term in the hierarchy can relate to multiple high...
Autores principales: | Kramer, Michael, Dutkowski, Janusz, Yu, Michael, Bafna, Vineet, Ideker, Trey |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4058954/ https://www.ncbi.nlm.nih.gov/pubmed/24932003 http://dx.doi.org/10.1093/bioinformatics/btu282 |
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